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B1814

Sigma-Aldrich

Bone Morphogenetic Protein 2 human

Carrier Free, ≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

BMP-2

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About This Item

MDL number:
MFCD03097877
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

Quality Level

200

recombinant

expressed in E. coli

assay

≥98% (SDS-PAGE)

form

lyophilized powder

mol wt

26 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

technique(s)

cell culture | mammalian: suitable

impurities

Endotoxin, tested

color

white

solubility

water: soluble 0.100 mL, clear, colorless

UniProt accession no.

P12643

storage temp.

−20°C

Gene Information

human ... BMP2(650)

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Biochem/physiol Actions

Cellular responses to BMP-2 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. BMPs stimulate angiogenesis by inducing the production of VEGF-A by osteoblasts. Human, mouse, and rat BMP-2 demonstrate 100% homology.

Physical form

Lyophilized from a 0.2 μm filtered buffered solution.

Analysis Note

The biological activity is measured by its ability to induce alkaline phosphatase production by ATDC5 chondrogenic cells.

wgk_germany

WGK 3

flash_point_f

104.0 °F

flash_point_c

40.0 °C

Certificates of Analysis (COA)

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Ernst B Hunziker et al.
Tissue engineering. Part A, 21(13-14), 2089-2098 (2015-04-22)
The articular cartilage layer of synovial joints is commonly lesioned by trauma or by a degenerative joint disease. Attempts to repair the damage frequently involve the performance of autologous chondrocyte implantation (ACI). Healthy cartilage must be first removed from the
Fengxuan Han et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 103(7), 1344-1353 (2014-11-12)
Repair of cartilage-bone interface tissue remains challenging, because it combines different cell types and gradients of composition and properties. To enable simultaneous regeneration of bone, cartilage, and especially their interface, a conically graded scaffold of chitosan-gelatin hydrogel/poly(l-lactide-co-glycolide) (PLGA) was facilely
Lindsay A Bonsignore et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(7), 979-987 (2015-02-14)
The most important factor contributing to short-term and long-term success of cementless total joint arthroplasties is osseointegration. Osseointegration leads to a direct structural and functional connection between living bone and the surface of an implant. Surface contaminants may remain on
Thorsten Pfirrmann et al.
Human molecular genetics, 24(11), 3119-3132 (2015-02-26)
Chordin-Like 1 (CHRDL1) mutations cause non-syndromic X-linked megalocornea (XMC) characterized by enlarged anterior eye segments. Mosaic corneal degeneration, presenile cataract and secondary glaucoma are associated with XMC. Beside that CHRDL1 encodes Ventroptin, a secreted bone morphogenetic protein (BMP) antagonist, the
Liping Wang et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(8), 1212-1217 (2015-03-17)
Available evidence indicates that some Tie2-expressing (Tie2(+) ) cells serve as multipotent progenitors that have robust BMP-dependent osteogenic activity and mediate heterotopic ossification (HO). Since signaling through the G protein Gi is required for cell motility, we hypothesized that blockade
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