Skip to Content
MilliporeSigma
All Photos(1)

Documents

A5353

Sigma-Aldrich

Apolipoprotein B from human plasma

≥95%, lyophilized powder

Synonym(s):

apoB

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

MDL number:
MFCD00130537
UNSPSC Code:
12352211
NACRES:
NA.25

biological source

human plasma

Quality Level

200

assay

≥95%

form

lyophilized powder

UniProt accession no.

P04114

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... APOB(338)

Looking for similar products? Visit Product Comparison Guide

Application


  • The common p.Ile291Val variant of ERLIN1 enhances TM6SF2 function and is associated with protection against MASLD.: This study investigates a variant of ERLIN1 and its role in enhancing TM6SF2 function, highlighting how Apolipoprotein B from human plasma contributes to understanding metabolic-associated liver disease (MASLD) protection (Rendel et al., 2024).

  • Blood Lipids, Lipoproteins, and Apolipoproteins With Risk of Coronary Heart Disease: A Prospective Study Among Racially Diverse Populations.: This prospective study evaluates the relationship between blood lipids, lipoproteins, Apolipoprotein B, and the risk of coronary heart disease across diverse populations, providing crucial insights into cardiovascular risk assessment (Deng et al., 2024).

  • The genomic landscape of Vk*MYC myeloma highlights shared pathways of transformation between mice and humans.: Research in this paper identifies shared pathways in myeloma transformation between mice and humans, utilizing Apolipoprotein B from human plasma to understand the molecular mechanisms involved in this process (Maura et al., 2024).


Biochem/physiol Actions

Apo-B levels correlate with the risk of coronary disease. Apo-B exists in human plasma in two isoforms, Apo-B48 and Apo-B100. Apo-B100 is the major physiological ligand for the LDL receptor. Apo-B100 is a large monomeric protein, containing 4563 amino acids (MW 515 kDa). Apo-B100 is synthesized in the liver and is required for the assembly of VLDL. It does not interchange between lipoprotein particles, as do the other apolipoproteins, and it is found in IDL and LDL after the removal of the Apo-A, E, and C. Apo-B48 is present in chylomicrons and their remnants. It is essential for the intestinal absorption of dietary lipids.
Apo-B48 is synthesized in the small intestine. It comprises approximately half of the N-terminal region of Apo-B100 and is the result of posttranscriptional mRNA editing by a stop codon in the intestine not found in the liver. The concentration of Apo-B in normal plasma is ~90 mg/dl.

Physical form

Lyophilized from buffer containing 10 mM sodium deoxycholate, 0.05 M sodium carbonate and 0.05 M sodium chloride, pH 10.0

Preparation Note

Delipidated with sodium deoxycholate.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Articles

Cholesterol Transport

Since cholesterol is a water-insoluble molecule it must be packaged for transport within the plasma. The particles that package cholesterol, cholesteryl esters, and triglycerides for transport, are called lipoproteins.

Omega-3 Fatty Acids and Heart Disease

The potential for the prevention and treatment of cardiovascular disease through increased dietary intake of omega-3 (w-3) fish oils is not a recent scientific discovery.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service