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PHR1723

Supelco

Desipramine Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Desipramine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C18H22N2 · HCl
CAS Number:
58-28-6
Molecular Weight:
302.84
EC Number:
200-373-1
MDL number:
MFCD00058108
UNSPSC Code:
41116107
PubChem Substance ID:
329823576
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to BP 931
traceable to Ph. Eur. D0500000
traceable to USP 1172006

API family

desipramine

CofA

current certificate can be downloaded

packaging

pkg of 400 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl[H].CNCCCN1c2ccccc2CCc3ccccc13

InChI

1S/C18H22N2.ClH/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20;/h2-5,7-10,19H,6,11-14H2,1H3;1H

InChI key

XAEWZDYWZHIUCT-UHFFFAOYSA-N

Gene Information

human ... SLC6A2(6530)

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Desipramine Hydrochloride is a salt of desipramine (DES), which is a tertiary amine based psychiatric drug used to treat depressive disorders. DES is classified under the group of tricyclic antidepressants (TADs).

Application

Desipramine Hydrochloride may be used as a pharmaceutical reference standard for the analysis of the analyte in pharmaceutical formulations by chromatography, colorimetric, and UV-densitometry methods.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA7398 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAC1473
LRAA7398

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Desipramine Hydrochloride
USP43-NF38
United States Pharmacopeia/National Formulary, 42(1), 1256-1256 (2017)
A sensitive colorimetric method for the determination of imipramine hydrochloride and desipramine hydrochloride
El-Yazbi FA, et al.
Journal of Clinical Pharmacy and Therapeutics, 10(4), 373-377 (1985)
UV-densitometric determination of maprotiline, desipramine and moclobemide in pharmaceutical dosage forms
Vujic Z, et al.
Chromatographia, 57(9-10), 687-689 (2003)
Validation of non-aqueous capillary electrophoresis for simultaneous determination of four tricyclic antidepressants in pharmaceutical formulations and plasma samples
Cantu M, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 799(1), 127-132 (2004)

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