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PHR1537

Supelco

Oxytetracycline

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Oxytetracycline dihydrate, OTC

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About This Item

Empirical Formula (Hill Notation):
C22H24N2O9 · 2H2O
CAS Number:
6153-64-6
Molecular Weight:
496.46
EC Number:
201-212-8
MDL number:
MFCD00151234
UNSPSC Code:
41116107
PubChem Substance ID:
329823449
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to BP 782
traceable to Ph. Eur. Y0001896
traceable to USP 1491004

API family

oxytetracycline

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

-10 to -25°C

SMILES string

O.[H][C@@]12[C@@H](O)[C@@]3([H])C(C(=O)c4c(O)cccc4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C

InChI

1S/C22H24N2O9.H2O/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29;/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31);1H2/t12-,13-,14+,17+,21-,22+;/m1./s1

InChI key

IBZHEBHGZFICKS-IFLJXUKPSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Oxytetracycline is a broad-spectrum antibiotic which finds a wide use in veterinary medicine because of its potential to inhibit the protein synthesis in gram-positive and gram-negative bacteria. It can be used on animal species like cattle, sheep, goats and pigs.

Application

Oxytetracycline may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography and spectrofluorimetry techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Antibiotic produced by Streptomyces rimosus.
Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Mode of Resistance: Active efflux, ribosome protection, tetracycline inactivation.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0364 in the slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.
Description
Pricing

1491015

Oxytetracycline hydrochloride, United States Pharmacopeia (USP) Reference Standard

1491004

Oxytetracycline, United States Pharmacopeia (USP) Reference Standard

O0500000

Oxytetracycline hydrochloride, European Pharmacopoeia (EP) Reference Standard

PHR1325

Oxytetracycline Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

BP782

Oxytetracycline, British Pharmacopoeia (BP) Reference Standard

BP275

Oxytetracycline hydrochloride, British Pharmacopoeia (BP) Reference Standard

Y0002136

Oxytetracycline for system suitability A, European Pharmacopoeia (EP) Reference Standard

PHR8912

alpha-Apo-oxytetracycline, certified reference material, pharmaceutical secondary standard

PHR8913

beta-Apo-oxytetracycline, certified reference material, pharmaceutical secondary standard

pictograms

Health hazardEnvironment
GHS08,GHS09

signalword

Warning

Hazard Classifications

Aquatic Chronic 2 - Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAB3717
LRAC0364
LRAB4155
LRAC6091
LRAB4115

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Gallego JML and Arroyo JP
Analytica Chimica Acta, 460(1), 85-97 (2002)
Quantitative analysis for oxytetracycline in medicated premixes and feeds by second-derivative synchronous spectrofluorimetry.
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C18 columns for the simultaneous determination of oxytetracycline and its related substances by reversed-phase high performance liquid chromatography and UV detection.
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