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PHR1525

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Rabeprazole Sodium

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Rabeprazole sodium, 2-([4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl)-1H-benzo[d]imidazole, Pariprazole

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About This Item

Empirical Formula (Hill Notation):
C18H20N3O3S · Na
CAS Number:
117976-90-6
Molecular Weight:
381.42
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to USP 1598019

API family

rabeprazole

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

[Na+].COCCCOc1ccnc(CS(=O)c2nc3ccccc3[n-]2)c1C

InChI

1S/C18H20N3O3S.Na/c1-13-16(19-9-8-17(13)24-11-5-10-23-2)12-25(22)18-20-14-6-3-4-7-15(14)21-18;/h3-4,6-9H,5,10-12H2,1-2H3;/q-1;+1

InChI key

KRCQSTCYZUOBHN-UHFFFAOYSA-N

Gene Information

human ... ATP4A(495) , ATP4B(496)

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General description

Rabeprazole Sodium belongs to the group of antisecretory compounds and is a proton pump inhibitor. It is widely used to suppress the gastric acid secretion by blocking the acid pump (H+ /K+ ATPase) at the secretory surface of the gastric parietal cell.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Rabeprazole Sodium may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using reversed-phase high-performance liquid chromatography technique and spectrophotometric technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Rabeprazole sodium is gastric proton pump inhibitor. It suppresses the production of acid in the stomach by inhibiting the gastric H+/K+ATPase (hydrogen-potassium adenosine triphosphatase) at the secretory surface of the gastric parietal cell. Rabeprazole sodium has been used clinically to treat acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevent gastroinetestinal bleeds associated with NSAID use.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA3643 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

Product No.
Description
Pricing

1598019

Rabeprazole sodium, United States Pharmacopeia (USP) Reference Standard

1598042

Rabeprazole Related Compound C, United States Pharmacopeia (USP) Reference Standard

1598064

Rabeprazole Related Compound E, United States Pharmacopeia (USP) Reference Standard

1598020

Rabeprazole Related Compound A, United States Pharmacopeia (USP) Reference Standard

1598053

Rabeprazole Related Compound D, United States Pharmacopeia (USP) Reference Standard

1598031

Rabeprazole Related Compound B, United States Pharmacopeia (USP) Reference Standard

1598075

Rabeprazole Related Compound F, United States Pharmacopeia (USP) Reference Standard

Y0001778

Rabeprazole for system suitability, European Pharmacopoeia (EP) Reference Standard

Y0001783

Rabeprazole sodium hydrate, CRS, European Pharmacopoeia (EP) Reference Standard

PHR3123

Rabeprazole Related Compound C, pharmaceutical secondary standard, certified reference material

PHR3124

Rabeprazole Related Compound E, pharmaceutical secondary standard, certified reference material

PHR3125

Rabeprazole Related Compound F, pharmaceutical secondary standard, certified reference material

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 4

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAC8801
LRAC9874
LRAB3892
LRAC8801
LRAA3643

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Development and validation of RP-HPLC for the rabeprazole sodium in pharmaceutical formulations and human plasma
Battu RP and Reddy SM
Asian Journal of Research in Chemistry, 2(1), 49-51 (2009)
Desk Reference of Clinical Pharmacology, 2(1), 49-51 (2009)
Spectrophotometric simultaneous determination of rabeprazole sodium and itopride hydrochloride in capsule dosage form
Sabnis SS, et al.
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 69(3), 849-852 (2008)

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