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PHR1334

Supelco

Folic Acid Impurity A

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

N-(4-Aminobenzoyl)-L-glutamic acid, N-(4-aminobenzoyl)-L-Glutamic acid

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About This Item

Empirical Formula (Hill Notation):
C12H14N2O5
CAS Number:
4271-30-1
Molecular Weight:
266.25
Beilstein/REAXYS Number:
2816320
EC Number:
224-261-7
MDL number:
MFCD00042821
UNSPSC Code:
41116107
PubChem Substance ID:
329823319
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to Ph. Eur. Y0001242
traceable to USP 1019870

API family

folic acid

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Nc1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O

InChI

1S/C12H14N2O5/c13-8-3-1-7(2-4-8)11(17)14-9(12(18)19)5-6-10(15)16/h1-4,9H,5-6,13H2,(H,14,17)(H,15,16)(H,18,19)/t9-/m0/s1

InChI key

GADGMZDHLQLZRI-VIFPVBQESA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3324 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

Product No.
Description
Pricing

F0300000

Folic acid, European Pharmacopoeia (EP) Reference Standard

PHR1035

Folic acid, Pharmaceutical Secondary Standard; Certified Reference Material

1286005

Folic acid, United States Pharmacopeia (USP) Reference Standard

Y0001242

Folic acid impurity A, European Pharmacopoeia (EP) Reference Standard

Y0001243

Folic acid impurity D, European Pharmacopoeia (EP) Reference Standard

C0250000

Calcium folinate, European Pharmacopoeia (EP) Reference Standard

1286027

Folic Acid Related Compound A, United States Pharmacopeia (USP) Reference Standard

1286300

10-Formylfolic acid, United States Pharmacopeia (USP) Reference Standard

1019870

4-Aminobenzoylglutamic acid, United States Pharmacopeia (USP) Reference Standard

BP937

Folic acid, British Pharmacopoeia (BP) Reference Standard

PHR2002

Folic Acid Impurity D, Pharmaceutical Secondary Standard; Certified Reference Material

Y0001979

Folic acid for system suitability, European Pharmacopoeia (EP) Reference Standard

Y0001980

Folic acid for impurity I identification, European Pharmacopoeia (EP) Reference Standard

Y0002071

Calcium folinate for system suitability, European Pharmacopoeia (EP) Reference Standard

PHR2003

Folic Acid Impurity F, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2334

10-Formylfolic Acid, Pharmaceutical Secondary Standard; Certified Reference Material

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD1921
LRAC3324
LRAA9128
LRAA0986

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Folate metabolism is essential for DNA synthesis and a validated drug target in fast-growing cell populations, including tumors and malaria parasites. Genome data suggest that Plasmodium has retained its capacity to generate folates de novo. However, the metabolic plasticity of

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