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PHR1244

Supelco

Lindane

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

gamma-hexachlorocyclohexane, γ-BHC, 1α,2α,3β,4α,5α,6β-Hexachlorocyclohexane

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About This Item

Empirical Formula (Hill Notation):
C6H6Cl6
CAS Number:
58-89-9
Molecular Weight:
290.83
Beilstein/REAXYS Number:
1907337
EC Number:
200-401-2
MDL number:
MFCD00135947
UNSPSC Code:
41116107
PubChem Substance ID:
329823248
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to USP 1367504

API family

lindane

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

113-115 °C (lit.)

application(s)

cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl[C@H]1[C@H](Cl)[C@H](Cl)[C@@H](Cl)[C@H](Cl)[C@@H]1Cl

InChI

1S/C6H6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H/t1-,2-,3-,4+,5+,6+

InChI key

JLYXXMFPNIAWKQ-GNIYUCBRSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Lindane is an organochlorine chemical, widely used as an agricultural insecticide and it also finds applications for the pharmaceutical treatment of infestations of lice and scabies.

Application

Lindane may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using gas chromatography technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA9048 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Danger

Hazard Classifications

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1 - Lact. - STOT RE 2

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD6120
LRAC5513
P500244
LRAA9048

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Simultaneous Determination by Gas Chromatography of Lindane and Carbaryl in Combined Formulations
Sen I, et al.
Journal of Chemistry, 8(1), 391-399 (2011)
Microbial degradation of the pesticide lindane (gamma-hexachlorocyclohexane).
B K Singh et al.
Advances in applied microbiology, 47, 269-298 (2003-07-25)
Yuji Nagata et al.
Applied microbiology and biotechnology, 76(4), 741-752 (2007-07-20)
gamma-Hexachlorocyclohexane (gamma-HCH, also called gamma-BHC and lindane) is a halogenated organic insecticide that causes serious environmental problems. The aerobic degradation pathway of gamma-HCH was extensively revealed in bacterial strain Sphingobium japonicum (formerly Sphingomonas paucimobilis) UT26. gamma-HCH is transformed to 2,5-dichlorohydroquinone
S E Aks et al.
Annals of emergency medicine, 26(5), 647-651 (1995-11-01)
Lindane toxicity has been reported to occur mostly by way of dermal exposure. Cases of ingestion in which blood levels have been determined are rare. We present three such cases, along with a comparison of cases in the literature with
John Vijgen et al.
Environmental science and pollution research international, 18(2), 152-162 (2010-11-26)
Hexachlorocyclohexane (HCH) isomers (α-, β- and γ- (Lindane)) were recently included as new persistent organic pollutants (POPs) in the Stockholm Convention, and therefore, the legacy of HCH and Lindane production became a contemporary topic of global relevance. This article wants
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