Skip to Content
MilliporeSigma
All Photos(1)

Documents

PHR1003

Supelco

Aspirin (Acetyl Salicylic Acid)

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Acetylsalicylic acid, 2-Acetoxybenzoic acid, O-Acetylsalicylic acid, ASA, Aspirin

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Linear Formula:
2-(CH3CO2)C6H4CO2H
CAS Number:
50-78-2
Molecular Weight:
180.16
Beilstein/REAXYS Number:
779271
EC Number:
200-064-1
MDL number:
MFCD00002430
UNSPSC Code:
41116107
PubChem Substance ID:
329823034
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to BP 617
traceable to Ph. Eur. A0200000
traceable to USP 1044006

API family

aspirin

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

134-136 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CC(=O)Oc1ccccc1C(O)=O

InChI

1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)

InChI key

BSYNRYMUTXBXSQ-UHFFFAOYSA-N

Gene Information

human ... PTGS1(5742) , PTGS2(5743)

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Aspirin (Acetyl Salicylic Acid) is a cyclo-oxygenase inhibitor and an antiplatelet agent, widely used for the secondary preventions of heart attack and stroke.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Aspirin (Acetyl Salicylic Acid) may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique and reversed-phase high-performance liquid chromatography technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Blocks the production of prostaglandins by inhibiting cyclooxygenase (prostaglandin H synthase), with greater selectivity toward the COX-1 isoform. The antithrombotic effect is due to the inhibition of COX-1 in platelets that blocks thromboxane production and platelet aggregation. Chemopreventive against colorectal and other solid tumors.
Blocks the production of prostaglandins by inhibiting cyclooxygenase (prostaglandin H synthase), with greater selectivity toward the COX-1 isoform. The antithrombotic effect is due to the inhibition of COX-1 in platelets that blocks thromboxane production and platelet aggregation. Chemopreventive against colorectal and other solid tumors.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7669 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

wgk_germany

WGK 1

flash_point_f

482.0 °F

flash_point_c

250 °C

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAB7669
LRAC6517
LRAA7459
LRAA1476
P500003

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 7

1 of 7

Acetaminophen BioXtra, ≥99.0%

Sigma-Aldrich

A7085

Acetaminophen

Orphenadrine Citrate Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1777

Orphenadrine Citrate

Phosphoric acid solution 85 wt. % in H2O, FCC, FG

Sigma-Aldrich

W290017

Phosphoric acid solution

Acetaminophen Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1005

Acetaminophen

Ibuprofen

Supelco

I110

Ibuprofen

Acetic anhydride Arxada quality, ≥99.5% (GC)

Sigma-Aldrich

691275

Acetic anhydride

Acetic anhydride ACS reagent, ≥98.0%

Sigma-Aldrich

242845

Acetic anhydride

Studies on the anti-inflammatory and analgesic activity of Cedrus deodara (Roxb.) Loud. wood oil
Shinde.AU, et al.
Journal of Ethnopharmacology, 65, 21-27 (1999)
Preliminary studies on the analgesic activity of latex of Calotropris procera
Dewan.S, et al.
Journal of Ethnopharmacology, 73, 307-311 (2000)
Simultaneous determination of clopidogrel and aspirin in pharmaceutical dosage forms
Mishra P and Dolly A
Indian Journal of Pharmaceutical Sciences, 63(3) (2006)
Rapid and simultaneous determination of aspirin and dipyridamole in pharmaceutical formulations by reversed-phase high performance liquid chromatography (RP-HPLC) method
Prakash K, et al.
African Journal of Pharmacy and Pharmacology, 5(2), 244-251 (2011)
Christina Perneby et al.
Thrombosis and haemostasis, 95(4), 652-658 (2006-04-08)
Aspirin is widely used, but dosages in different clinical situations and the possible importance of "aspirin resistance" are debated. We performed an open cross-over study comparing no treatment (baseline) with three aspirin dosage regimens--37.5 mg/day for 10 days, 320 mg/day
View All Related Papers

Articles

HPLC Analysis of Pain Relievers on Ascentis® Express C18

Separation of Acetaminophen, meets USP testing specifications, 98.0-102.0%, powder; Caffeine, meets USP testing specifications, anhydrous; Benzoic acid, meets USP testing specifications; Aspirin, meets USP testing specifications

Protocols

HPLC Analysis of Aspirin and Salicylic Acid on Ascentis® Express RP-Amide

Separation of Acetylsalicylic acid, analytical standard; Salicylic acid, BioXtra, ≥99.0%

HPLC Analysis of Salicylic Acid and Acetylsalicylic Acid (Aspirin) on Ascentis® Express OH5

Separation of Salicylic acid, meets analytical specification of Ph. Eur., BP, USP, 99.5-100.5% (calc. to the dried substance); Acetylsalicylic acid, purum, ≥99.0% (HPLC)

HPLC Analysis of Benzoic Acid and Related Compounds on Ascentis® RP-Amide

Separation of 4-Hydroxybenzoic acid; Acetylsalicylic acid; Benzoic acid; Salicylic acid; Ethyl 4-hydroxybenzoate

HPLC Analysis of Benzoic Acid Derivatives on Ascentis® C18

HPLC Analysis of Benzoic Acid Derivatives on Ascentis® C18

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service