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P5631

Sigma-Aldrich

o-Cresolphthalein Complexone

powder

Synonym(s):

o-Cresolphthalein-3′,3′′-bis-methyleneiminodiacetic acid, o-Cresolphthalexon, Metal phthalein, Phthalein purple, Xylenylphthalein-bisiminodiacetic acid

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About This Item

Empirical Formula (Hill Notation):
C32H32N2O12
CAS Number:
2411-89-4
Molecular Weight:
636.60
Beilstein/REAXYS Number:
381994
EC Number:
219-318-8
MDL number:
MFCD00005911
UNSPSC Code:
12171500
PubChem Substance ID:
24898682
NACRES:
NA.47

Quality Level

200

mp

181-185 °C (dec.) (lit.)

solubility

methanol: 1 mg/mL

suitability

suitable for determination of calcium

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

Cc1cc(cc(CN(CC(O)=O)CC(O)=O)c1O)C2(OC(=O)c3ccccc23)c4cc(C)c(O)c(CN(CC(O)=O)CC(O)=O)c4

InChI

1S/C32H32N2O12/c1-17-7-21(9-19(29(17)43)11-33(13-25(35)36)14-26(37)38)32(24-6-4-3-5-23(24)31(45)46-32)22-8-18(2)30(44)20(10-22)12-34(15-27(39)40)16-28(41)42/h3-10,43-44H,11-16H2,1-2H3,(H,35,36)(H,37,38)(H,39,40)(H,41,42)

InChI key

IYZPEGVSBUNMBE-UHFFFAOYSA-N

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General description

o-Cresolphthalein Complexone is a pH indicator dye commonly used for the calorimetric determination of calcium in serum.

Application

o-Cresolphthalein Complexone has been used in the estimation of calcium in serum samples based on the reaction of Ca2+ with o-cresolphthalein complexone in an alkaline solution.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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J Toffaletti et al.
Clinical chemistry, 26(11), 1562-1565 (1980-10-01)
We adapted a method for dialyzable calcium from fluorometric detection by use of calcein to a more specific spectrophotometric determination with cresolphthalein complexone. The reagents are available commercially and perform satisfactorily with respect to noise level, drift, stability, and sensitivity.
Improved determination of serum calcium with 2-cresolphthalein complexone.
K Lorentz
Clinica chimica acta; international journal of clinical chemistry, 126(3), 327-334 (1982-12-23)
Improved linearity of the calcium-cresolphthalein complexone reaction with sodium acetate.
D M Cowley et al.
Clinical chemistry, 32(5), 894-895 (1986-05-01)
C M Corns et al.
Annals of clinical biochemistry, 24 ( Pt 4), 345-351 (1987-07-01)
The reasons for the non-linearity of the standard curve for the calcium-cresolphthalein complexone reaction have been investigated. Calcium forms both 1:1 and 2:1 complexes with cresolphthalein complexone; at low calcium concentrations the 1:1 complex predominates and causes non-linearity. At high
Sandra F Williams et al.
Mayo Clinic proceedings, 80(12), 1655-1657 (2005-12-14)
Severe hypocalcemia may require prompt intervention to avoid life-threatening consequences. We report a case in which a 78-year-old man had a critically low serum calcium level measured with use of standard colorimetric assay after gadodiamide administration during magnetic resonance angiography.
View All Related Papers

Protocols

Suitability for the qualitative determination of calcium with phthalein purple (O-cresophthalein complexone) using stannous chloride

Suitability for the Qualitative Determination of Calcium with Phthalein Purple (O-Cresophthalein Complexone) using Stannous Chloride

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