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LIGHTOX21

Sigma-Aldrich

LightOx21

≥95% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C21H21NO2
CAS Number:
Molecular Weight:
319.40
UNSPSC Code:
12352200

assay

≥95% (HPLC)

form

powder

storage temp.

2-8°C

Inchi Code

1S/C21H21NO2/c1-21(2)12-13-22(3)19-11-8-16(14-18(19)21)5-4-15-6-9-17(10-7-15)20(23)24/h6-11,14H,12-13H2,1-3H3,(H,23,24)

InChI key

WQRGZQYIDRZUOE-UHFFFAOYSA-N

Related Categories

Application

Fluorescence microscopy, fluorescent retinoid binding assay, fluorescence spectroscopy.

Biochem/physiol Actions

Strong ligand for retinoic acid receptor proteins

Features and Benefits

LightOx21 is a synthetic analogue of all-trans-retinoic acid (ATRA), that exhibits solvatochromatic fluorescence emission when excited with UV or 405 nm light. The compound is a strong ligand for the retinoic acid receptor proteins (RARs) and related cellular retinoic acid binding proteins (CRABPI/II) and can, therefore, be used as a replacement for ATRA in cellular assays involving retinoid signaling processes. LightOx21 can be utilised to study retinoid behaviour using fluorescence microscopy, employed in a competitive fluorometric ligand-binding assay for direct determination of the strength of binding of non-fluorescent retinoids to a protein target, and as a fluorophore in fluorescence spectroscopy.

Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)

Other Notes

Chemical Equivalency 1ea=1mg

Legal Information

LightOx is a trademark of LightOx Ltd.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Articles

Fluorescent retinoic acid analogues for use in cellular imaging, protein-ligand binding assays, and flow cytometry to bypass traditional problems associated with fluorescent probes.

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