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BP578

Dexamethasone

British Pharmacopoeia (BP) Assay Standard

Synonym(s):

(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16α-methylprednisolone, Prednisolone F

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About This Item

Empirical Formula (Hill Notation):
C22H29FO5
CAS Number:
50-02-2
Molecular Weight:
392.46
Beilstein/REAXYS Number:
2066651
EC Number:
200-003-9
MDL number:
MFCD00064136
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

dexamethasone

form

solid

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

BP

mp

262-264 °C (lit.)

application(s)

pharmaceutical

format

neat

storage temp.

2-8°C

SMILES string

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChI key

UREBDLICKHMUKA-CXSFZGCWSA-N

Gene Information

human ... NR3C1(2908)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dexamethasone BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Tobramycin and Dexamethasone Eye Drops, Suspension
  • Dexamethasone Sodium Phosphate Oral Solution
  • Hydrocortisone Sodium Succinate Injection
  • Prednisolone Tablets
  • Dexamethasone Eye Drops, Suspension
  • Dexamethasone Sodium Phosphate Eye Drops, Solution
  • Dexamethasone and Neomycin Ear Spray
  • Betamethasone Tablets
  • Dexamethasone Tablets

    • Biochem/physiol Actions

    Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.

    Other Notes

    Sales restrictions may apply.

    related product

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    Pricing

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    Dexamethasone phosphate, United States Pharmacopeia (USP) Reference Standard

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    Dexamethasone acetate, European Pharmacopoeia (EP) Reference Standard

    D0720000

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    D0700000

    Dexamethasone, European Pharmacopoeia (EP) Reference Standard

    Y0000538

    Dexamethasone isonicotinate, European Pharmacopoeia (EP) Reference Standard

    Y0001177

    Dexamethasone for system suitability, European Pharmacopoeia (EP) Reference Standard

    Y0001169

    Dexamethasone acetate impurity E, European Pharmacopoeia (EP) Reference Standard

    Y0001477

    Dexamethasone sodium phosphate for peak identification, European Pharmacopoeia (EP) Reference Standard

    Y0001593

    Dexamethasone for peak identification, European Pharmacopoeia (EP) Reference Standard

    1176506

    Dexamethasone acetate, United States Pharmacopeia (USP) Reference Standard

    1176007

    Dexamethasone, United States Pharmacopeia (USP) Reference Standard

    PHR1527

    Dexamethasone Acetate, Pharmaceutical Secondary Standard; Certified Reference Material

    PHR1628

    Dexamethasone Phosphate, Pharmaceutical Secondary Standard; Certified Reference Material

    BP811

    Dexamethasone impurity standard, British Pharmacopoeia (BP) Reference Standard

    pictograms

    Health hazard
    GHS08

    signalword

    Danger

    hcodes

    H360FD

    Hazard Classifications

    Repr. 1B

    Storage Class

    6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

    wgk_germany

    WGK 3

    flash_point_f

    Not applicable

    flash_point_c

    Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number

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    Sigma-Aldrich

    D2915

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    Sigma-Aldrich

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    Sigma-Aldrich

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    A Keith Stewart et al.
    The New England journal of medicine, 372(2), 142-152 (2014-12-09)
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    The objective of this study was to evaluate the safety and efficacy of allogeneic bone marrow mesenchymal stromal/stem cell transplantation (BM-MSCT) for patients with ursodeoxycholic acid (UDCA)-resistant primary biliary cirrhosis (PBC). Ten patients were enrolled in this trial of BM-MSCT.
    Michael J White et al.
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    Activated caspases are a hallmark of apoptosis induced by the intrinsic pathway, but they are dispensable for cell death and the apoptotic clearance of cells in vivo. This has led to the suggestion that caspases are activated not just to kill
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