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B7522

Supelco

Benfluorex hydrochloride

analytical standard

Synonym(s):

N-(1-Methyl-2-(3-[trifluoromethyl]-phenyl)ethyl]aminoethanol benzoate ester

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About This Item

Empirical Formula (Hill Notation):
C19H20F3NO2 · HCl
CAS Number:
23642-66-2
Molecular Weight:
387.82
EC Number:
245-801-8
MDL number:
MFCD00058493
UNSPSC Code:
41116107
PubChem Substance ID:
329773296
NACRES:
NA.24

grade

analytical standard

Quality Level

200

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

Cl.CC(Cc1cccc(c1)C(F)(F)F)NCCOC(=O)c2ccccc2

InChI

1S/C19H20F3NO2.ClH/c1-14(12-15-6-5-9-17(13-15)19(20,21)22)23-10-11-25-18(24)16-7-3-2-4-8-16;/h2-9,13-14,23H,10-12H2,1H3;1H

InChI key

NLOALSPYZIIXEO-UHFFFAOYSA-N

Gene Information

human ... SOAT1(6646)

Related Categories

General description

Benfluorex hydrochloride salt is a hypolipidaemic compound with lipid and glucose lowering effects.
It is used in the treatment of impaired carbohydrate metabolism, atherogenic metabolic disorders and in the suppression of appetite.

Application

Benfluorex hydrochloride may be used as a reference standard for characterization of human urinary metabolites of benfluorex by gas chromatography–electron ionization–mass spectrometry (GC-EI-MS) as well as liquid chromatography–electrospray ionization–high resolution/high accuracy tandem mass spectrometry (LC-ESI-MS/MS) method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
087F0342

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Agnès Fournier et al.
Pharmacoepidemiology and drug safety, 21(4), 343-351 (2012-02-10)
To estimate the number of deaths from valvular insufficiency caused by the use of the fenfluramine-derivative benfluorex during the period 1976-2009 in France. Our calculation was based on (i) the exposure level to benfluorex in the French population, derived from
Screening for benfluorex and its major urinary metabolites in routine doping controls.
Thevis M, et al.
Analytical and Bioanalytical Chemistry, 401(2), 543-551 (2011)
Thermal and X-ray powder diffraction structural characterization of two benfluorex hydrochloride polymorphs.
Maccaroni E, et al.
Journal of Pharmaceutical and Biomedical Analysis, 53(1), 1-6 (2010)
Nam Sook Kim et al.
Rapid communications in mass spectrometry : RCM, 35(3), e8989-e8989 (2020-10-27)
Recently, illegal dietary supplements containing unauthorized compounds have been seized and internationally publicized with a warning to avoid their consumption. This adulteration can be a serious threat to public health because of insufficient and reliable safety data as well as
Benfluorex and cardiac valve disease: long delay in publication.
Prescrire international, 22(135), 47-47 (2013-02-28)
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