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Sigma-Aldrich

Magnesium stearate

puriss., meets analytical specification of Ph. Eur., BP, ≥90% stearic and palmitic acid basis, ≥40% stearic acid basis (GC), 4.0-5.0% Mg basis (calc on dry sub.)

Synonym(s):

Stearic acid magnesium salt

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About This Item

Linear Formula:
[CH3(CH2)16CO2]2Mg
CAS Number:
557-04-0
Molecular Weight:
591.24
Beilstein/REAXYS Number:
3919702
EC Number:
209-150-3
MDL number:
MFCD00036391
UNSPSC Code:
12352106
PubChem Substance ID:
57648176
NACRES:
NA.22

grade

puriss.

assay

≥40% stearic acid basis (GC)
≥90% stearic and palmitic acid basis
4.0-5.0% Mg basis (calc on dry sub.)

quality

meets analytical specification of Ph. Eur., BP

impurities

acidity or alkalinity, complies
 microbiological impurity, in accordance
 residual solvents, complies

loss

≤6.0% loss on drying, 105 °C

mp

200 °C (lit.)

acid value

195‑210(fatty acid)

solubility

alcohol: insoluble
diethyl ether: insoluble
water: insoluble

anion traces

chloride (Cl-): ≤1000 mg/kg
sulfate (SO42-): ≤5000 mg/kg

cation traces

Cd: ≤3 mg/kg
Ni: ≤5 mg/kg
Pb: ≤10 mg/kg

suitability

in accordance for fatty acid composition
passes test for identity

application(s)

pharmaceutical (small molecule)

SMILES string

CCCCCCCCCCCCCCCCCC(=O)O[Mg]OC(=O)CCCCCCCCCCCCCCCCC

InChI

1S/2C18H36O2.Mg/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2

InChI key

HQKMJHAJHXVSDF-UHFFFAOYSA-L

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Application

Magnesium stearate has been used as a tablet and capsule lubricant. It has also been used for preparing microcapsules.

Biochem/physiol Actions

Magnesium stearate is the magnesium salt of stearic acid that possess lubricating properties and hence prevents ingredients from sticking to manufacturing equipment during the compression of chemical powders into solid tablets. Dry coating of drugs with magnesium stearate leads to flow improvement, flow-aid and lubrication effects, tabletability as well as non-inhibited dissolution rate.

Storage Class

11 - Combustible Solids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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