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MAB2637

Sigma-Aldrich

Anti-Integrin beta-3 (CD61) Antibody, clone HMb3-1

clone HMb3-1, from hamster(Armenian)

Synonym(s):

CD61 antigen, Platelet membrane glycoprotein IIIa, integrin beta chain, beta 3, integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61), platelet glycoprotein IIIa, GPIIIa

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

hamster (Armenian)

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

HMb3-1, monoclonal

species reactivity

mouse

technique(s)

flow cytometry: suitable
immunohistochemistry: suitable

isotype

IgG

NCBI accession no.

NP_058060.2

UniProt accession no.

O54890

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

mouse ... Itgb3(16416)

Related Categories

General description

The integrin family of cell adhesion receptors consists of several membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor. The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented.

Platelet membrane glycoprotein Integrin beta3 or CD61 (GP IIIa) forms a Ca2+-dependent heterodimer complex with GP IIb. The GP IIb-IIIa complex constitutes the fibrinogen and fibronectin receptor on stimulated platelets.

Specificity

The antibody recognizes Integrin beta-3.

Immunogen

Recombinant protein corresponding to mouse Integrin beta-3.

Application

Detect Integrin beta-3 (CD61) using this Anti-Integrin beta-3 (CD61) Antibody, clone HMb3-1 validated for use in FC, IH.
Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH (Piali, 1995).

Quality

Evaluated by Flow Cytometry on mouse bone marrow-derived cells.

Flow Cytometry Analysis: 0.1-1 µg/mL of the antibody detected Integrin beta-3 on mouse bone marrow-derived cells

Target description

~ 86-87 kDa

Physical form

Format: Purified

Analysis Note

Control
Mouse bone marrow-derived cells

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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IGF-I enhances ?5?1 integrin expression and cell motility in human chondrosarcoma cells.
Chi-Ming Wu,Te-Mao Li,Sheng-Feng Hsu,Yi-Chang Su,Shung-Te Kao,Yi-Chin Fong,Chih-Hsin Tang
Journal of Cellular Physiology null

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