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ABC337

Sigma-Aldrich

Anti-BAFF receptor Antibody

from rabbit, purified by affinity chromatography

Synonym(s):

Tumor necrosis factor receptor superfamily member 13C, B-cell-activating factor receptor, BAFF receptor, BAFF-R, BLyS receptor 3, CD268

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat, human, mouse

technique(s)

immunohistochemistry: suitable
western blot: suitable

UniProt accession no.

Q96RJ3

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... TNFRSF13C(115650)

General description

B-cell-activating factor receptor (BAFF receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C) and BLyS receptor 3 (BR3), is a member of the TNF superfamily that regulate immune responses and induce apoptosis. BAFF receptor promotes the survival of mature B-cells and the B-cell response. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-kB and c-jun N-terminal kinase. BAFF receptor is highly expressed in spleen and lymph node, with lower levels found in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes. Mutations in BAFF receptor have been associated with immunodeficiency common variable type 4 (CVID4), also called BAFFR defect.

Specificity

This antibody recognizes the C-terminus of BAFF receptor.

Immunogen

KLH-conjugated linear peptide corresponding to the C-terminus of human BAFF receptor.

Application

Detect B-cell-activating factor receptor using this rabbit polyclonal antibody, Anti-BAFF receptor Antibody validated for use in western blotting & IHC.
Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected BAFF receptor in human tonsil tissue.

Quality

Evaluated by Western Blotting in human, mouse, and rat spleen tissue lysates.

Western Blotting Analysis: 5 µg/mL of this antibody detected BAFF receptor in 15 µg of human, mouse, and rat spleen tissue lysates.

Target description

~22 kDa observed. Uniprot describes two isoforms at ~19 kDa Uncharacterized bands may appear in some lysates.

Analysis Note

Control
Human, mouse, and rat spleen tissue lysates

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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