Skip to Content
MilliporeSigma
All Photos(1)

Documents

AB15417

Sigma-Aldrich

Anti-Beclin 1 Antibody

serum, Chemicon®

Synonym(s):

Coiled-coil myosin-like BCL2-interacting protein, BECN1

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NM_003766.2

UniProt accession no.

Q14457

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... BECN1(8678)

General description

Autophagy is the process by which cells recycle cytoplasm and dispose of excess or defective organelles. This process is suggested to be involved development, differentiation, growth regulation and tissue remodeling in multicellular organisms. Beclin 1 is a BCL-2 interacting protein and this protein was shown to play a role in the promotion of autophagy.

Specificity

Beclin 1 [Coiled-coil myosin-like BCL2-interacting protein, BECN1].

Immunogen

Synthetic peptide corresponding to the C-terminus of human Beclin 1 protein.

Application

Detect Beclin 1 using this Anti-Beclin 1 Antibody validated for use in WB, IC, IH.
Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Western blot: 1:100-1:2,000
Immunocytochemistry: 1:100-1:2,000
Immunohistochemistry: 1:100-1:2,000
Optimal working dilutions must be determined by end user.

Linkage

Replaces: MABN16

Physical form

Lyophilized. Reconstitute with 50 μL of sterile distilled water. Centrifuge to remove any insoluble material. Contains no preservative.
Serum

Storage and Stability

Maintain lyophilized material frozen at -20°C to -70°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1, ACS or better grade) can be added for additional stability.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

recommended

Product No.
Description
Pricing

Storage Class

10 - Combustible liquids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation.
Iwata, Atsushi, et al.
Proceedings of the National Academy of Sciences of the USA, 102, 13135-13140 (2005)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service