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324412

Sigma-Aldrich

Dynamin Inhibitor III, Phthaladyn-23

Synonym(s):

Dynamin Inhibitor III, Phthaladyn-23, 4-Chloro-2-((2-(3-nitrophenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carbonyl)-amino)-benzoic acid

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About This Item

Empirical Formula (Hill Notation):
C22H12ClN3O7
Molecular Weight:
465.80
UNSPSC Code:
12352200

assay

≥98% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

light yellow to beige

solubility

DMSO: 7 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

A cell-permeable phthalimide compound that is reported to inhibit dynamin GTPase activity (IC50 = 17.4 and 63 µM using purified sheep brain dynamin I and recombinant dynamin II, respectively) in a GTP-competitive manner. Shown to block K+-induced SVE (synaptic vesicle endocytosis) of FM4-64 dye into rat brain synaptosomes (IC50 = 12.9 µM), while being ineffective at 30 µM against RME (receptor-mediated endocytosis) of transferrin into human osteosarcoma epithelial U2OS cells, presumably due to poor dynamin II inhibitory potency and/or rapid efflux and/or limited permeability in this cell line.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Odell, L.R., et al. 2010. J. Med. Chem.53, 5267.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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