Skip to Content
MilliporeSigma
All Photos(1)

Documents

1.02497

Supelco

NMP

for headspace gas chromatography SupraSolv®

Synonym(s):

1-Methyl-2-pyrrolidone, NMP, N-Methyl-2-pyrrolidone

Sign Into View Organizational & Contract Pricing


About This Item

CAS Number:
Molecular Weight:
99.13
MDL number:
UNSPSC Code:
41116105
EC Index Number:
212-828-1
NACRES:
NA.03

product name

1-Methyl-2-pyrrolidone, for headspace gas chromatography SupraSolv®

vapor pressure

0.32 hPa ( 20 °C)

Quality Level

product line

SupraSolv®

assay

≥99.8% (GC)

form

liquid

autoignition temp.

245 °C

potency

3598 mg/kg LD50, oral (Rat)
8000 mg/kg LD50, skin (Rabbit)

expl. lim.

1.3-9.5 % (v/v)

technique(s)

GC-HS: suitable

pH

8.5-10.0 (20 °C, 100 g/L in H2O)

bp

202 °C/1013 hPa

mp

-24 °C

transition temp

flash point 91 °C

solubility

1000 g/L

density

1.03 g/cm3 at 20 °C

storage temp.

2-30°C

InChI

1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3

InChI key

SECXISVLQFMRJM-UHFFFAOYSA-N

Related Categories

General description

SupraSolv® high-purity solvents are specially designed for headspace-gas chromatography (HS-GC) for the analysis of residual solvents (RS) in active pharmaceutical ingredients, excipients and drug products according to Ph. Eur and USP. The concentrations of RS for high purity solvents are specified following ICH (International Council for Harmonizaton of Technical Requirements for Registration of Pharmaceuticals for Human Use) Guideline Q3C “Impurities: Guideline for Residual Solvents”.

Application

Intended for sensitive detection of analytes of ICH classes 1, 2 and 3 in residue and environmental analysis:

Every residual solvent of class 1 acc. ICH ≤ 1 μg/g
Every residual solvent of class 2 acc. ICH ≤ 10 μg/g
Every residual solvent of class 3 acc. ICH ≤ 50 μg/g

Other Notes

Explore various lab safety accessories and equipment for safe handling of solvents to increase your safety level from the first usage.

Legal Information

SUPRASOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation markHealth hazard

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 1

flash_point_f

195.8 °F - Pensky-Martens closed cup

flash_point_c

91 °C - Pensky-Martens closed cup


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 6

1 of 6

Methylpyrrolidone United States Pharmacopeia (USP) Reference Standard

USP

1437202

Methylpyrrolidone

N,N-Dimethylacetamide for headspace gas chromatography SupraSolv®

Supelco

1.00399

N,N-Dimethylacetamide

N,N-Dimethylformamide for headspace gas chromatography SupraSolv®

Supelco

1.00202

N,N-Dimethylformamide

N-Methylpyrrolidone Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1352

N-Methylpyrrolidone

Benzyl alcohol for headspace gas chromatography SupraSolv®

Supelco

1.02695

Benzyl alcohol

Related Content

Gas chromatography separates volatile compounds in the gas phase, applied in various industries for quality control.

Gas chromatography separates volatile compounds in the gas phase, applied in various industries for quality control.

Gas chromatography is a common analytic technique used to separate and analyze volatile compounds in the gas phase. GC is applied in many industries for quality control, and to identify and/or quantify compounds in a mixture.

Gas chromatography is a common analytic technique used to separate and analyze volatile compounds in the gas phase. GC is applied in many industries for quality control, and to identify and/or quantify compounds in a mixture.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service