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880120P

Avanti

18:0 PEG2000 PE

Avanti Polar Lipids

Synonym(s):

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)

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About This Item

CAS Number:
474922-77-5
UNSPSC Code:
12352211

form

powder

packaging

pkg of 1 × 1 g (880120P-1g)
pkg of 1 × 200 mg (880120P-200mg)
pkg of 1 × 25 mg (880120P-25mg)
pkg of 1 × 500 mg (880120P-500mg)

manufacturer/tradename

Avanti Polar Lipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCCNC(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+]

General description

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000 (18:0 PEG2000 PE) is conjugate, covalently attached to polyethylene glycol (PEG2000). It forms a stable micelle of 180kDa with phosphoethanolamine as hydrophobic core and hydrophilic PEG2000 as outer micelle surface.

Application

18:0 PEG2000 PE may be used in the nickel resin functionalization of quantum dots. It may also be used in liposome preparation.

Biochem/physiol Actions

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000 (18:0 PEG2000 PE) is an effective drug carrier and is biocompatible. PEG stabilizes and protects the micelle from phagocytic system. The use of PEG as a conjugate with phospholipids enables improved liposome preparation and effective drug encapsulation.

Packaging

20 mL Clear Glass Screw Cap Vial (880120P-1g)
20 mL Clear Glass Screw Cap Vial (880120P-500mg)
5 mL Amber Glass Screw Cap Vial (880120P-200mg)
5 mL Amber Glass Screw Cap Vial (880120P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Relationship between targeting efficacy of liposomes and the dosage of targeting antibody using surface plasmon resonance
Xiang Y, et al.
Langmuir, 31(44), 12177-12186 (2015)
Structure and dynamics of highly PEG-ylated sterically stabilized micelles in aqueous media
Vukovic L, et al.
Journal of the American Chemical Society, 133(34), 13481-13488 (2011)
Characterization of 1, 2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[Methoxy (polyethylene glycerol)-2000] and Its Complex with Doxorubicin Using Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics
Hu W, et al.
Bioconjugate Chemistry, 28(6), 1777-1790 (2017)
Inertial cavitation to non-invasively trigger and monitor intratumoral release of drug from intravenously delivered liposomes
Graham SM, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 178, 101-107 (2014)
Ling Ye et al.
Nanotheranostics, 3(1), 54-65 (2019-01-22)
Rationale: Despite growing use of engineered nanomaterials (ENM) in applications from electronics to medicine, the potential risk to human health remains a critical concern within clinical use. ENM exposure during pregnancy can potentially cause reproductive toxicity even at levels that
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