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810192C

Avanti

16:0-06:0 NBD PS

Avanti Polar Lipids 810192C

Synonym(s):

1-palmitoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphoserine (ammonium salt)

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About This Item

Empirical Formula (Hill Notation):
C34H59N6O13P
CAS Number:
384833-06-1
Molecular Weight:
790.84
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (810192C-1mg)

manufacturer/tradename

Avanti Polar Lipids 810192C

concentration

1 mg/mL (810192C-1mg)

shipped in

dry ice

storage temp.

−20°C

General description

Phosphatidylserine (PS) is a minor phospholipid present in the membranes of prokaryotic and eukaryotic cells. It comprises 2-10% of total phospholipids, enriched in brain. NBD PS is labelled at the headgroup of PS with 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD).

Application

16:0-06:0 NBD PS or 1-palmitoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphoserine (ammonium salt) is suitable to measure the enzyme specificity of lipoteichoic acid (LTA) synthase (LtaS) and in liposomes to determine the role of phospholipid scramblase 1 (PLSCR1) in phospholipid scrambling.

Biochem/physiol Actions

Phosphatidylserine (PS) contributes to the clearance of apoptotic cells. It is involved in maintaining the nerve cell membrane and myelin sheath. It is associated with cognitive disability in Alzheimer′s disease.

Packaging

5 mL Amber Glass Screw Cap Vial (810192C-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

Certificates of Analysis (COA)

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Mirka E Wörmann et al.
Molecular microbiology, 79(3), 566-583 (2011-01-25)
Lipoteichoic acid (LTA) is an important cell wall polymer in Gram-positive bacteria. The enzyme responsible for polyglycerolphosphate LTA synthesis is LtaS, first described in Staphylococcus aureus. Four LtaS orthologues, LtaS(BS) , YfnI, YqgS and YvgJ, are present in Bacillus subtilis.
Maria Karatsa-Dodgson et al.
Journal of bacteriology, 192(20), 5341-5349 (2010-08-17)
Lipoteichoic acid (LTA) is an important cell wall component of Gram-positive bacteria. The key enzyme responsible for polyglycerolphosphate lipoteichoic acid synthesis in the Gram-positive pathogen Staphylococcus aureus is the membrane-embedded lipoteichoic acid synthase enzyme, LtaS. It is presumed that LtaS

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