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P63204

Sigma-Aldrich

2,3-Pyridinedicarboxylic acid

99%

Synonym(s):

Quinolinic acid

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About This Item

Empirical Formula (Hill Notation):
C7H5NO4
CAS Number:
89-00-9
Molecular Weight:
167.12
Beilstein/REAXYS Number:
137110
EC Number:
201-874-8
MDL number:
MFCD00006295
UNSPSC Code:
12352100
PubChem Substance ID:
24278005
NACRES:
NA.22

Quality Level

100

assay

99%

form

powder

mp

188-190 °C (dec.) (lit.)

SMILES string

OC(=O)c1cccnc1C(O)=O

InChI

1S/C7H5NO4/c9-6(10)4-2-1-3-8-5(4)7(11)12/h1-3H,(H,9,10)(H,11,12)

InChI key

GJAWHXHKYYXBSV-UHFFFAOYSA-N

Gene Information

rat ... Gria1(50592) , Grin2a(24409)

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Related Categories

Application

Inhibits glucose synthesis.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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L Garcia-Salguero et al.
Archives internationales de physiologie, de biochimie et de biophysique, 99(3), 237-242 (1991-06-01)
The in vitro and in vivo effects of several different inhibitors of carbohydrate metabolism have been studied. The in vitro addition of 5-methoxyindole-2-carboxylic acid (MICA), pent-4-enoic acid, and quinolinic acid to the perfusion medium significantly inhibited liver gluconeogenesis in 48-hour-starved
Dorit Cohen-Carmon et al.
Molecular neurobiology, 57(3), 1768-1777 (2019-12-14)
Huntington's disease (HD) is a neurodegenerative late-onset genetic disorder caused by CAG expansions in the coding region of the Huntingtin (HTT) gene, resulting in a poly-glutamine (polyQ) expanded HTT protein. Considerable efforts have been devoted for studying HD and other
Valéry Combes et al.
Trends in parasitology, 28(8), 311-319 (2012-06-26)
Homeostasis implies constant operational defence mechanisms, against both external and internal threats. Infectious agents are prominent among such threats. During infection, the host elicits the release of a vast array of molecules and numerous cell-cell interactions are triggered. These pleiomorphic
Gilles J Guillemin
The FEBS journal, 279(8), 1356-1365 (2012-01-18)
Over the last two decades, evidence for the involvement of quinolinic acid (QUIN) in neuroinflammatory diseases has been exponentially increasing. Within the brain, QUIN is produced and released by infiltrating macrophages and activated microglia, the very cells that are prominent
Gilles J Guillemin et al.
Neuro-degenerative diseases, 2(3-4), 166-176 (2006-08-16)
The kynurenine pathway (KP) is a major route of L-tryptophan catabolism leading to production of several neurobiologically active molecules. Among them is the excitotoxin quinolinic acid (QUIN) that is known to be involved in the pathogenesis of several major inflammatory
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