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460524

Sigma-Aldrich

Ethyl (S)-(−)-4-chloro-3-hydroxybutyrate

96%

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About This Item

Linear Formula:
ClCH2CH(OH)CH2CO2C2H5
CAS Number:
86728-85-0
Molecular Weight:
166.60
Beilstein/REAXYS Number:
4657170
MDL number:
MFCD00211241
UNSPSC Code:
12352101
PubChem Substance ID:
24869707
NACRES:
NA.22

Quality Level

100

assay

96%

optical activity

[α]23/D −14°, neat

optical purity

ee: 97% (GLC)

refractive index

n20/D 1.453 (lit.)

bp

93-95 °C/5 mmHg (lit.)

density

1.19 g/mL at 25 °C (lit.)

SMILES string

CCOC(=O)C[C@H](O)CCl

InChI

1S/C6H11ClO3/c1-2-10-6(9)3-5(8)4-7/h5,8H,2-4H2,1H3/t5-/m0/s1

InChI key

ZAJNMXDBJKCCAT-YFKPBYRVSA-N

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General description

Ethyl (S)-4-chloro-3-hydroxybutanoate is a chiral intermediate generally used to prepare atorvastatin, a cholesterol-lowering drug.

Application

Ethyl (S)-(−)-4-chloro-3-hydroxybutyrate can be used as a starting material in the synthesis of 4-amino-3-hydroxybutyric acid, a compound of pharmacological importance.

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Certificates of Analysis (COA)

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Short synthesis of (R)-and (S)-4-amino-3-hydroxybutyric acid (GABOB).
Tiecco M, et al.
Synthesis, 2005(04), 579-582 (2005)

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