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299154

Sigma-Aldrich

L-Methionine-(methyl-13C,d3)

≥99 atom % 13C, ≥99 atom % D, ≥99% (CP)

Synonym(s):

SILAC Amino Acid

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About This Item

Linear Formula:
13CD3SCH2CH2CH(NH2)CO2H
CAS Number:
73488-65-0
Molecular Weight:
153.22
MDL number:
MFCD00002624
UNSPSC Code:
12352209
PubChem Substance ID:
24858018
NACRES:
NA.12

isotopic purity

≥99 atom % 13C
≥99 atom % D

Quality Level

200

assay

≥99% (CP)

form

powder

optical activity

[α]25/D +23.1°, c = 1 in 1 M HCl

technique(s)

protein expression: suitable

mp

284 °C (dec.) (lit.)

mass shift

M+4

SMILES string

[2H][13C]([2H])([2H])SCC[C@H](N)C(O)=O

InChI

1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1/i1+1D3

InChI key

FFEARJCKVFRZRR-ZIHWZSJBSA-N

Related Categories

Application

Used in the methodology of stable isotope tagging of epitopes (SITE) for identification of virus-induced peptides in vaccine development.

Packaging

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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L-Methionine

Martin Bachman et al.
Nature chemical biology, 11(8), 555-557 (2015-06-23)
5-Formylcytosine (5fC) is a rare base found in mammalian DNA and thought to be involved in active DNA demethylation. Here, we show that developmental dynamics of 5fC levels in mouse DNA differ from those of 5-hydroxymethylcytosine (5hmC), and using stable
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Science signaling, 12(575) (2019-04-04)
Protein arginine methyltransferases (PRMTs) catalyze arginine methylation on both chromatin-bound and cytoplasmic proteins. Accumulating evidence supports the involvement of PRMT5, the major type II PRMT, in cell survival and differentiation pathways that are important during development and in tumorigenesis. PRMT5
Martin Bachman et al.
Nature chemistry, 6(12), 1049-1055 (2014-11-21)
5-Hydroxymethylcytosine (hmC) is an oxidation product of 5-methylcytosine which is present in the deoxyribonucleic acid (DNA) of most mammalian cells. Reduction of hmC levels in DNA is a hallmark of cancers. Elucidating the dynamics of this oxidation reaction and the

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