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124753

Sigma-Aldrich

Succinamide

98%

Synonym(s):

Succinic diamide

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About This Item

Linear Formula:
NH2COCH2CH2CONH2
CAS Number:
110-14-5
Molecular Weight:
116.12
Beilstein/REAXYS Number:
1753983
EC Number:
203-739-9
MDL number:
MFCD00008042
UNSPSC Code:
12352100
PubChem Substance ID:
24847626
NACRES:
NA.22

Quality Level

100

assay

98%

mp

260-265 °C (dec.) (lit.)

solubility

cold water: soluble 220 part
boiling water: soluble 9 part
alcohol: insoluble
diethyl ether: insoluble

SMILES string

NC(=O)CCC(N)=O

InChI

1S/C4H8N2O2/c5-3(7)1-2-4(6)8/h1-2H2,(H2,5,7)(H2,6,8)

InChI key

SNCZNSNPXMPCGN-UHFFFAOYSA-N

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Application

Succinamide has been used in the characterization of a novel biuret hydrolase from the cysteine hydrolase superfamily. It was used as nitrogen supplement in the culture medium of Scenedesmus obliquus and green algae.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Birgit T Priest et al.
Biochemistry, 43(30), 9866-9876 (2004-07-28)
Sodium channel blockers are used clinically to treat a number of neuropathic pain conditions, but more potent and selective agents should improve on the therapeutic index of currently used drugs. In a high-throughput functional assay, a novel sodium channel (Na(V))
Petras P Dzeja et al.
American journal of physiology. Heart and circulatory physiology, 284(4), H1048-H1056 (2003-04-02)
Modulation of mitochondrial respiratory chain, dehydrogenase, and nucleotide-metabolizing enzyme activities is fundamental to cellular protection. Here, we demonstrate that the potassium channel opener diazoxide, within its cardioprotective concentration range, modulated the activity of flavin adenine dinucleotide-dependent succinate dehydrogenase with an
T Watanabe et al.
Chemical & pharmaceutical bulletin, 45(6), 996-1007 (1997-06-01)
A series of 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one derivatives containing the succinamide skeleton has been synthesized and evaluated for M1, M2 and M3 muscarinic receptor binding affinities (in vitro) and M2 and M3 muscarinic receptor antagonistic activities (in vivo). Some of them showed higher
Xiaobin Zhang et al.
Drug delivery, 11(5), 301-309 (2005-03-04)
To investigate the effect of RMP-7 and its derivative on drug transport across blood brain barrier (BBB), RMP-7 and DSPE-PEG-NHS [1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-n-[poly(ethyleneglycol)]-hydroxy succinamide, PEG M 3400] were conjugated under mild conditions and the reaction ratio was determined using MALDI-TOF-MS (matrix-assisted laser
Olaf F A Larsen et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(38), 13378-13382 (2005-09-10)
Femtosecond 2D-IR spectroscopy has been used to study the structure of a [2]rotaxane composed of a benzylic amide macrocycle that is mechanically interlocked onto a succinamide-based thread. Both the macrocycle and the thread contain carbonyl groups, and by determining the
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