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1317007

USP

Hydrocortisone acetate

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Hydrocortisone 21-acetate, 11β,17α,21-Trihydroxy-4-pregnene-3,20-dione 21-acetate, 17-α-Hydroxycorticosterone acetate, 17-Hydroxycorticosterone 21-acetate, 21-Acetoxy-4-pregnene-11β,17α-diol-3,20-dione, 4-Pregnene-11β,17α,21-triol-3,20-dione 21-acetate

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About This Item

Empirical Formula (Hill Notation):
C23H32O6
CAS Number:
50-03-3
Molecular Weight:
404.50
Beilstein:
2066841
MDL number:
MFCD00037714
UNSPSC Code:
41116107
PubChem Substance ID:
329750076

grade

pharmaceutical primary standard

API family

hydrocortisone

manufacturer/tradename

USP

mp

223 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)COC(C)=O

InChI

1S/C23H32O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-18,20,26,28H,4-9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1

InChI key

ALEXXDVDDISNDU-JZYPGELDSA-N

Gene Information

human ... NR3C1(2908)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Hydrocortisone acetate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monographs such as:
  • Hydrocortisone Acetate Cream
  • Hydrocortisone Acetate Lotion
  • Hydrocortisone Acetate Ointment
  • Neomycin Sulfate and Hydrocortisone Acetate Ointment
  • Neomycin Sulfate and Hydrocortisone Acetate Ophthalmic Suspension
  • Oxytetracycline Hydrochloride and Hydrocortisone Acetate Ophthalmic Suspension
  • Neomycin and Polymyxin B Sulfates and Hydrocortisone Acetate Cream

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

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Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H360Df - H373

Hazard Classifications

Repr. 1B - STOT RE 2

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Adamo Fini et al.
AAPS PharmSciTech, 9(3), 762-768 (2008-06-20)
The purpose of this research was the preparation of four formulations containing hydrocortisone acetate (HCA) for topical application, including two aqueous systems (hydrophilic microemulsion and aqueous gel) and two systems with dominant hydrophobicity (hydrophobic microemulsion and ointment). The formulations were
Janyce A Sugui et al.
Journal of clinical microbiology, 52(10), 3707-3721 (2014-08-08)
Aspergillus section Fumigati contains 12 clinically relevant species. Among these Aspergillus species, A. fumigatus is the most frequent agent of invasive aspergillosis, followed by A. lentulus and A. viridinutans. Genealogical concordance and mating experiments were performed to examine the relationship
Timothy Kassis et al.
PLoS neglected tropical diseases, 8(11), e3305-e3305 (2014-11-21)
Lymphatic Filariasis, a Neglected Tropical Disease, is caused by thread-like parasitic worms, including B. malayi, which migrate to the human lymphatic system following transmission. The parasites reside in collecting lymphatic vessels and lymph nodes for years, often resulting in lymphedema
Dan-Ni Wang et al.
Medical mycology, 52(5), 506-518 (2014-05-23)
Gliotoxin is an important virulence factor of Aspergillus fumigatus. Although GliA putatively belongs to the major facilitator superfamily in the gliotoxin biosynthesis cluster, its roles remain unclear. To determine the function of GliA, we disrupted gliA in A. fumigatus. gliA

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