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SML2749

Sigma-Aldrich

iFSP1

≥98% (HPLC)

Synonym(s):

1-Amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile, 1-Amino-3-(p-tolyl)benzo[4,5]imidazo[1,2-a]pyridine-2,4-dicarbonitrile, 1-Amino-3-p-tolyl-benzo[4,5]imidazo[1,2-a]pyridine-2,4-dicarbonitrile

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About This Item

Empirical Formula (Hill Notation):
C20H13N5
CAS Number:
150651-39-1
Molecular Weight:
323.35
MDL number:
MFCD01572665
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

NC1=C(C#N)C(C2=CC=C(C)C=C2)=C(C#N)C3=NC4=C(C=CC=C4)N31

Biochem/physiol Actions

iFSP1 is a potent selective inhibitor of ferroptosis-suppressor-protein 1 (FSP1) that induces ferroptosis in cancer cells. iFSP1 strongly synergizes with GPX4 inhibitors to initiate ferroptosis in cancer cells.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sebastian Doll et al.
Nature, 575(7784), 693-698 (2019-10-22)
Ferroptosis is an iron-dependent form of necrotic cell death marked by oxidative damage to phospholipids1,2. To date, ferroptosis has been thought to be controlled only by the phospholipid hydroperoxide-reducing enzyme glutathione peroxidase 4 (GPX4)3,4 and radical-trapping antioxidants5,6. However, elucidation of

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