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SML0174

Sigma-Aldrich

GPR35 Agonist, Compound 10

≥98% (HPLC)

Synonym(s):

2-[4-[(2,4-Dioxo-5-thiazolidinylidene)methyl]phenoxy]-acetic acid

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About This Item

Empirical Formula (Hill Notation):
C12H9NO5S
CAS Number:
123021-85-2
Molecular Weight:
279.27
MDL number:
MFCD01835940
UNSPSC Code:
12352200
PubChem Substance ID:
329825204
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥5 mg/mL at ~60 °C

storage temp.

2-8°C

SMILES string

OC(=O)COc1ccc(cc1)\C=C2/SC(=O)NC2=O

InChI

1S/C12H9NO5S/c14-10(15)6-18-8-3-1-7(2-4-8)5-9-11(16)13-12(17)19-9/h1-5H,6H2,(H,14,15)(H,13,16,17)/b9-5-

InChI key

WXMCOLGPDOYHNK-UITAMQMPSA-N

Application

GPR35 Agonist, Compound 10, may be used in GPR35-mediated cell signaling studies.

Biochem/physiol Actions

GPR35 agonist Compound 10 is a GPR35 agonist the binds with higher affinity than other known agonists, such as kynurenic acid and zaprinast. Compound 10 was more potent than zaniprast (pEC50 = 5.3 vs 4.18) for recombinantly expressed human GPR35, and unlike zaprinast, is equipotent for human and rat GPR35

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Ida Marie Modvig et al.
American journal of physiology. Endocrinology and metabolism, 320(5), E874-E885 (2021-03-02)
The aim of this study was to explore individual amino acid-stimulated GLP-1 responses and the underlying stimulatory mechanisms, as well as to identify the amino acid-sensing receptors involved in amino acid-stimulated GLP-1 release. Experiments were primarily based on isolated perfused

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