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M4255

Sigma-Aldrich

3-Methoxy-L-tyrosine monohydrate

powder

Synonym(s):

4-Hydroxy-3-methoxy-L-phenylalanine, L-3-O-Methyl-DOPA

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About This Item

Empirical Formula (Hill Notation):
C10H13NO4 H2O
CAS Number:
200630-46-2
Molecular Weight:
229.23
MDL number:
MFCD00150495
UNSPSC Code:
12352209
PubChem Substance ID:
24896916
NACRES:
NA.26

Assay

≥98% (HPLC)

Quality Level

100

form

powder

application(s)

detection

storage temp.

2-8°C

SMILES string

COc1cc(C[C@H](N)C(O)=O)ccc1O

InChI

1S/C10H13NO4/c1-15-9-5-6(2-3-8(9)12)4-7(11)10(13)14/h2-3,5,7,12H,4,11H2,1H3,(H,13,14)/t7-/m0/s1

InChI key

PFDUUKDQEHURQC-ZETCQYMHSA-N

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Biochem/physiol Actions

3-Methoxy-L-tyrosine is a metabolite of L-Dopa.
The major metabolite of L-DOPA via catechol O-methyltransferase (COMT). 3-methoxy-L-tyrosine is neither a substrate for nor an inhibitor of L-amino acid decarboxylase activity. Inhibition of COMT enhances the anti-Parkinson activity of L-DOPA.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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United States Pharmacopeia (USP) Reference Standard

USP

1095517

Carbidopa Related Compound A

≥98% (HPLC), crystalline

Sigma-Aldrich

H8876

5-Hydroxyindole-3-acetic acid

solid

Sigma-Aldrich

D1507

L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride

97%

Sigma-Aldrich

472727

3-(3,4-Dimethoxyphenyl)-L-alanine

Homovanillic acid analytical standard

Supelco

69673

Homovanillic acid

99% (AT)

Sigma-Aldrich

65390

3-Methoxytyramine hydrochloride

Chiara Muzzi et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 62(4), 253-258 (2007-12-26)
Levodopa is the medication of choice for Parkinson's disease. The biological complexity of levodopa and of its main derivatives makes their determination important in the clinical field. The aim of this study was to develop an HPLC method for the

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