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E9505

Sigma-Aldrich

β-Estradiol 3-sulfate sodium salt

≥93%

Synonym(s):

1,3,5(10)-Estratriene-3,17β-diol 3-sulfate, 3,17β-Dihydroxy-1,3,5(10)-estratriene 3-sulfate

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About This Item

Linear Formula:
C18H23O5SNa
CAS Number:
4999-79-5
Molecular Weight:
374.43
MDL number:
MFCD00056553
UNSPSC Code:
12352200
PubChem Substance ID:
24894699
NACRES:
NA.77

sterility

non-sterile

Quality Level

200

Assay

≥93%

form

powder

contains

~70% N-methyl-D-glucamine as stabilizer

solubility

methanol: 9.80-10.20 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

room temp

SMILES string

[Na].[H][C@]12CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(OS(O)(=O)=O)ccc24

InChI

1S/C18H24O5S.Na.H/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;;/h3,5,10,14-17,19H,2,4,6-9H2,1H3,(H,20,21,22);;/t14-,15-,16+,17+,18+;;/m1../s1

InChI key

PYPVMTJYMKHIST-LBARCDFESA-N

General description

β-Estradiol is secreted by developing ovaries and is predominant during premenopause in women.

Application

β-Estradiol 3-sulfate sodium salt has been used to measure the estradiol level from culture supernatant in ultra-performance liquid chromatography-tandem mass spectrometry.

Biochem/physiol Actions

β-Estradiol is a steroid hormone involved in a number of organ functions. It is significantly associated with brain functions including neuroprotection, neurogenesis and synaptic plasticity. β-Estradiol maintains bone homeostasis, hence it is preferred for osteoporosis therapy. 17-β-Estradiol is the most active estrogen generated in our body. During postmenopausal, 17-β-estradiol inhibits oxidative modification in low density lipoprotein. This indicates that estrogen replacement therapy might be useful in treating cardiovascular disease.

Packaging

Package size based on steroid content

Pictograms

Exclamation markHealth hazard
GHS07,GHS08

Signal Word

Warning

Hazard Statements

H302 + H332 - H351

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J M Green et al.
Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire, 61(1), 15-22 (1983-01-01)
A radioisotopic assay for cytoplasmic estradiol-17 beta sulfotransferase activity in rat liver was developed. Routine enzyme assays used 120 microM [3H]estradiol-17 beta, 240 microM 3'-phosphoadenosine-5'-phosphosulfate, and enzyme samples containing up to 0.60 mg of cytosol protein. Livers from males and
Layer-by-Layer Films for Biomedical Applications, 517-517 (2014)
Bioactive Natural Products: Chemistry and Biology, 375-375 (2015)
The in vitro metabolism of estrone and estradiol-17 beta and their 3-sulfates by the renal tissues from pregnant and female fetal guinea-pigs.
G L Adessi et al.
Journal of steroid biochemistry, 15, 453-459 (1981-12-01)
Y M Qian et al.
The Journal of biological chemistry, 276(9), 6404-6411 (2000-12-05)
Multidrug resistance protein 1 (MRP1) is an ATP-binding cassette (ABC) transporter that transports a range of hydrophobic xenobiotics, as well as relatively hydrophilic organic anion conjugates. The protein is present at high levels in testicular Leydig and Sertoli cells. Studies
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Separation of Estriol 3-(β-D-glucuronide) sodium salt; β-Estradiol 3-(β-D-glucuronide) 17-sulfate dipotassium salt; Estriol 3-sulfate sodium salt; β-Estradiol 3,17-disulfate dipotassium salt, ≥95%; β-Estradiol 17-(β-D-glucuronide) sodium salt; β-Estradiol 3-(β-D-glucuronide) sodium salt; Estrone 3-(β-D-glucuronide) sodium salt; β-Estradiol 3-sulfate sodium salt, ≥93%; Estriol, ≥97%; Estrone 3-sulfate sodium salt, contains ~35% Tris as stabilizer; β-Estradiol, ≥98%; α-Estradiol, powder, ≥98% (TLC); Estrone, ≥99%

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