D6694
Anti-DSCR1 (C-terminal) antibody produced in rabbit
~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-ADAP78, Anti-Calcipressin 1, Anti-DSC1, Anti-Down Syndrome Candidate Region 1, Anti-MCIP1, Anti-Myocyte-enriched calcineurin-interacting protein 1, Anti-RCAN1, Anti-RCN1, Anti-Regulator of calcineurin 1
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.44
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~26 kDa
species reactivity
mouse, rat, human
concentration
~1.5 mg/mL
technique(s)
western blot: 2-4 μg/mL using HEK-293T cells expressing human DSCR1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... RCAN1(1827)
mouse ... Dscr1(54720)
rat ... Dscr1(266766)
General description
DSCR1 (Down Syndrome Candidate Region 1 is encoded by a gene mapped to human chromosome 21q22.1. DSCR1 belongs to a family of conserved proteins named regulators of calcineurin (RCAN), that in humans include RCAN, encoded by the DSCR1L1-2 genes. DSCR1 is highly expressed in the central nervous system (CNS) during early embryonic development, in heart, and in skeletal muscle.
Specificity
Anti-DSCR1 (C-terminal) antibody is specific for DSCR1 in rats, mice and humans. The immunizing peptide specifically inhibits the staining of DSCR1 by immunoblotting.
Immunogen
Synthetic peptide corresponding to a sequence at C-terminal of human DSCR1, conjugated to KLH. This sequence is identical in human DSCR1 isoforms a and b, and rat and mouse DSCR1.
Application
Anti-DSCR1 (C-terminal) antibody is suitable for use in western blot (2-4 μg/mL using HEK-293T cells expressing human DSCR1) and in immunoblotting (approx. 26 kDa).
Anti-DSCR1 (C-terminal) antibody produced in rabbit has been used in proximity ligation assay (PLA) and immunoblotting.
Biochem/physiol Actions
Down Syndrome Candidate Region 1 (DSCR1) is involved in cellular adaptation to oxidative stress, and interacts with calcineurin to inhibit its phosphatase activity, thereby regulating the calcineurin- Nuclear factor of activated T-cells (NFAT) signaling pathway and affecting central nervous system (CNS) development and angiogenesis. Chronic overexpression of DSCR1 has been implicated in additional pathological conditions including Alzheimer′s disease and cardiac hypertrophy, possibly through inhibition of calcineurin activity. DSCR1 is induced by vascular endothelial growth factor (VEGF) in activated endothelial cells and regulates the expression of inflammatory marker genes such as interleukin-8 (IL-8), tissue factor, E-selectin and cyclooxygenase (Cox-2).
Down Syndrome Candidate Region 1 or DSCR1 is a candidate gene involved in the pathogenesis of Down′s Syndrome (DS). DSCR1 is usually expressed in cardiac, skeletal and brain tissues, whereas its overexpression in fetal brain tissues is associated with DS. DSCR1 inhibits calcineurin-mediated mRNA synthesis.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2)
Strippoli P, et al.
Genomics, 64(3), 252-263 (2000)
Glucose-regulated protein 78 is essential for cardiac myocyte survival
Wang X, et al.
Cell Death and Differentiation, 25(12), 2181-2181 (2018)
Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells
Hesser BA, et al.
Blood, 104(1), 149-158 (2004)
Marshall W Hogarth et al.
Human molecular genetics, 25(5), 866-877 (2015-12-19)
A common null polymorphism (R577X) in ACTN3 causes α-actinin-3 deficiency in ∼ 18% of the global population. There is no associated disease phenotype, but α-actinin-3 deficiency is detrimental to sprint and power performance in both elite athletes and the general
Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture
Villahoz S, et al.
Nature Communications, 9(1), 4795-4795 (2018)
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