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D1069

Sigma-Aldrich

Desloratadine

powder, ≥98% (HPLC)

Synonym(s):

8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H- benzo[5,6]cyclohepta[1,2,b]pyridine, Clarinex®, NSC 675447

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About This Item

Empirical Formula (Hill Notation):
C19H19ClN2
CAS Number:
100643-71-8
Molecular Weight:
310.82
MDL number:
MFCD00871949
UNSPSC Code:
12352200
PubChem Substance ID:
329798668
NACRES:
NA.32

Quality Level

100

Assay

≥98% (HPLC)

form

powder

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

Clc1ccc2c(CCc3cccnc3\C2=C4\CCNCC4)c1

InChI

1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2

InChI key

JAUOIFJMECXRGI-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

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Application

Desloratadine has been used to test its effect on embryoid body development in in vitro gastrulation model of P19C5 stem cells. It has also been used as an antihistamine mimic in rats and to treat lung cancer (A549) and glioblastoma (U87) cells in various cellular studies.

Biochem/physiol Actions

Desloratadine is a selective and nonsedating histamine H1 receptor antagonist, an active metabolite of loratadine (Claritin), used to relieve hay fever and allergy symptoms with less drowsiness than other antihistamines; does not significantly inhibits cardiac K+ channels at clinically achievable blood levels. Free from antimuscarinic/anticholinergic effects.

Legal Information

Clarinex is a registered trademark of Schering Corp.

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WGK

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Flash Point(F)

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Flash Point(C)

Pensky-Martens closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Gasheva OY, et al.
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