Skip to Content
Merck
All Photos(1)

Documents

A6428

Sigma-Aldrich

Aflatoxin M1

from Aspergillus flavus

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C17H12O7
CAS Number:
6795-23-9
Molecular Weight:
328.27
EC Number:
229-865-4
MDL number:
MFCD00871812
UNSPSC Code:
12352200
PubChem Substance ID:
24891088
NACRES:
NA.77

biological source

Aspergillus flavus

Quality Level

200

form

film

storage temp.

2-8°C

SMILES string

[H][C@]12OC=C[C@@]1(O)c3c(O2)cc(OC)c4C5=C(C(=O)CC5)C(=O)Oc34

InChI

1S/C17H12O7/c1-21-9-6-10-13(17(20)4-5-22-16(17)23-10)14-12(9)7-2-3-8(18)11(7)15(19)24-14/h4-6,16,20H,2-3H2,1H3/t16-,17-/m1/s1

InChI key

MJBWDEQAUQTVKK-IAGOWNOFSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Aflatoxins are metabolites of fungus, that are mainly seen in feeds and foods. Aflatoxin M1 is a hydroxylated metabolite of aflatoxin B1. It is liberated in milk, urine and produced in liver after receiving aflatoxin B1.

Application

Aflatoxin M1 has been used as a standard to investigate the incidence and occurrence of aflatoxin M1 (AFM1) in Brazilian milk and infant formula. It has also been used as standard to investigate the incidence and occurrence of aflatoxin M1 (AFM1) in dairy products produced in Brazil.
Aflatoxin M1 is both a hepatotoxic and hepatocarcinogenic mycotoxin that has been shown to cause immunosuppression in animals.

Biochem/physiol Actions

Aflatoxin M1 possesses hepatocarcinogenic properties.

Warning

Possibly carcinogenic.

Preparation Note

Aspergillus flavus metabolite.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Carc. 1B - Muta. 1B

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 3

1 of 3

Aflatoxin G1

Supelco

32756

Aflatoxin G1

Supelco

Supelco

34036

Aflatoxin Mix 4 solution

vibrant-m

ERMBD284

Whole milk powder

Marcin Ratajewski et al.
Toxicology letters, 205(2), 146-153 (2011-06-07)
Pregnane X receptor (PXR) is a member of the nuclear hormone receptor (NHR) superfamily, which regulates xenobiotic and endobiotic metabolism in the liver. This transcription factor is activated by structurally diverse ligands, including drugs and environmental pollutants. PXR regulates the
Occurrence of aflatoxin M1 in dairy products in Brazil
Iha MH, et al.
Food Control, 22(12), 1971-1974 (2011)
Aflatoxin B1 and M1: Biological properties and their involvement in cancer development
Marchese S, et al.
Toxins, 10(6), 214-214 (2018)
Aflatoxins
Handbook of Secondary Fungal Metabolites, 545-569 (2003)
Aflatoxins
Handbook of Secondary Fungal Metabolites (2003)
View All Related Papers

Articles

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.

Protocols

LC/MS Analysis of Aflatoxin M1 in Milk on Ascentis® Express HILIC after SPE using Supel™ Tox AflaZea, Quantifying Picogram Concentrations

Protocol for LC/MS Analysis of Aflatoxin M1 in Milk on Ascentis® Express HILIC after SPE using Supel™ Tox AflaZea, Quantifying Picogram Concentrations

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service