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PHR2363

Supelco

Menaquinone -7

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Vitamin K2-(MK-7), (all-E)–2-(3,7,11,15,19,23,27-Heptamethyl-2,6,10,14,18,22,26-octacosaheptaenyl)-3-methyl-1,4-naphthalenedione

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About This Item

Empirical Formula (Hill Notation):
C46H64O2
CAS Number:
2124-57-4
Molecular Weight:
649.00
UNSPSC Code:
41116107

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1381119

API family

menaquinone

form

solid

CofA

current certificate can be downloaded

packaging

pkg of 3x75 mg

storage temp.

-10 to -25°C

InChI

1S/C46H64O2/c1-34(2)18-12-19-35(3)20-13-21-36(4)22-14-23-37(5)24-15-25-38(6)26-16-27-39(7)28-17-29-40(8)32-33-42-41(9)45(47)43-30-10-11-31-44(43)46(42)48/h10-11,18,20,22,24,26,28,30-32H,12-17,19,21,23,25,27,29,33H2,1-9H3/b35-20+,36-22+,37-24+,38-26+,39-28+,40-32+

InChI key

RAKQPZMEYJZGPI-LJWNYQGCSA-N

Related Categories

General description

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Menaquinone -7 is a naphthoquinone derivative and one of the most active sub-type of vitamin K2, with 7 referring to the number of isoprene units in its structure. It is naturally found in fermented dairy products and is considered a nutrient, thereby being found as a component of various nutritional supplements.

Application

This pharmaceutical secondary standard can also be used as follows:
  • Ultra high-performance liquid chromatography (UHPLC) based determination of menaquinone-7 and vitamin D3 in their combined tablet formulation
  • Development of a thin-layer chromatographic-densitometric technique for the quantitative analysis of vitamins K and D3 in pharmaceutical tablet formulations and dietary supplements
  • Simultaneous determination of vitamin D3 and K2 (Menaquinone-4 and Menaquinone-7) in dietary supplements by ultra-high-pressure liquid chromatography (UHPLC)
  • Impurity profiling of menaquinone-7 in its active pharmaceutical ingredient (API) samples using HPLC coupled to UV detector
  • Analysis of menaquinone-4 and menaquinone-7 by HPLC in combination with tandem mass spectrometry (MS/MS) in human milk samples

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC4030 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD4510
LRAC4030
LRAC9882

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Łukasz Jedynak et al.
Journal of pharmaceutical and biomedical analysis, 135, 116-125 (2016-12-27)
An HPLC method with UV detection and separation with the use of a C30 reversed phase analytical column for the determination of chemical purity and assay of menaquinone-7 (MK7) in one chromatographic run was developed. The method is superior to

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