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PHR1616

Supelco

Granisetron Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Granisetron hydrochloride, 1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C18H24N4O· HCl
CAS Number:
107007-99-8
Molecular Weight:
348.87
MDL number:
MFCD01747034
UNSPSC Code:
41116107
PubChem Substance ID:
329823512
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. Y0000396
traceable to USP 1298106

API family

granisetron

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl.CN1[C@H]2CCC[C@@H]1C[C@@H](C2)NC(=O)c3nn(C)c4ccccc34

InChI

1S/C18H24N4O.ClH/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17;/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23);1H/t12-,13+,14-;

InChI key

QYZRTBKYBJRGJB-WQTKJZBYSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Granisetron Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations, and human plasma samples employed in bioequivalence studies by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Granisetron hydrochloride is a serotonin 5-HT3 receptor antagonist and antiemetic.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA4875 in the slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.
Description
Pricing

Y0000396

Granisetron hydrochloride, European Pharmacopoeia (EP) Reference Standard

Y0000395

Granisetron impurity E, European Pharmacopoeia (EP) Reference Standard

Y0000477

Granisetron impurity A, European Pharmacopoeia (EP) Reference Standard

Y0000478

Granisetron impurity B, European Pharmacopoeia (EP) Reference Standard

1298140

Granisetron Related Compound D, United States Pharmacopeia (USP) Reference Standard

1298117

Granisetron Related Compound A, United States Pharmacopeia (USP) Reference Standard

1298128

Granisetron Related Compound B, United States Pharmacopeia (USP) Reference Standard

1298106

Granisetron hydrochloride, United States Pharmacopeia (USP) Reference Standard

1298139

Granisetron Related Compound C, United States Pharmacopeia (USP) Reference Standard

1298150

Granisetron Related Compound E, United States Pharmacopeia (USP) Reference Standard

1298092

Granisetron, United States Pharmacopeia (USP) Reference Standard

PHR2871

Granisetron Related Compound D, pharmaceutical secondary standard, certified reference material

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAC1751
LRAA4875

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Rapid determination of granisetron in human plasma by liquid chromatography coupled to tandem mass spectrometry and its application to bioequivalence study.
Jiang Y, et al.
Journal of Pharmaceutical and Biomedical Analysis, 42(4), 464-473 (2006)
Stability-indicating HPLC-DAD method for the determination of Granisetron hydrochloride in its pharmaceutical preparations.
Mabrouk M, et al.
Journal of Applied Pharmaceutical Science, 3(6), 189-189 (2013)
Ismail Hewala et al.
Journal of AOAC International, 94(5), 1447-1460 (2011-12-15)
A simple, rapid, and sensitive RP-HPLC method using photodiode array detection was developed and validated for the simultaneous determination of granisetron hydrochloride, 1-methyl-1H-indazole-3-carboxylic acid (the main degradation product of granisetron), sodium benzoate, methylparaben, propylparaben, and 4-hydroxybenzoic acid (the main degradation

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