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PHR1485

Supelco

Hydroxypropyl Cellulose

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Hydroxypropyl cellulose, HPC

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About This Item

CAS Number:
9004-64-2
MDL number:
MFCD00132688
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1329800

API family

hydroxypropyl cellulose

CofA

current certificate can be downloaded

autoignition temp.

752 °F

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

density

0.5 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

InChI

1S/C12H20N2/c1-5-12(13)11-7-6-10(14(3)4)8-9(11)2/h6-8,12H,5,13H2,1-4H3

InChI key

RRHXDYJWVYFMKV-UHFFFAOYSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Hydroxypropyl Cellulose is a cellulose ether which is formed by the chemical interaction of the hydroxyl groups with the glucose residues of cellulose at positions 2, 3, and/or 6. It is typically utilized as a drug excipient.

Application

Hydroxypropyl Cellulose may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography, colorimetric and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3473 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD3405
LRAC3473
LRAA3033
LRAA9228

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Sigma-Aldrich

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Determination of surface-bound hydroxypropylcellulose (HPC) on drug particles in colloidal dispersions using size exclusion chromatography: A comparison of ELS and RI detection
Zhu L, et al.
Journal of Pharmaceutical and Biomedical Analysis, 40(5), 1089-1096 (2006)
Spectrophotometric determination of omeprazole, lansoprazole and pantoprazole in pharmaceutical formulations
Wahbi AAM, et al.
Journal of Pharmaceutical and Biomedical Analysis, 30(4), 1133-1142 (2002)
Quantitation of poloxamers in pharmaceutical formulations using size exclusion chromatography and colorimetric methods
Mao Y, et al.
Journal of Pharmaceutical and Biomedical Analysis, 35(5), 1127-1142 (2004)
Detection and quantification of low-molecular-weight aldehydes in pharmaceutical excipients by headspace gas chromatography
Li Z, et al.
Journal of Chromatography A, 1104(1-2), 1-10 (2006)

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