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PHR1424

Supelco

Ampicillin Sodium

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Ampicillin sodium salt, D-(−)-α-Aminobenzylpenicillin sodium salt

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About This Item

Empirical Formula (Hill Notation):
C16H18N3NaO4S
CAS Number:
69-52-3
Molecular Weight:
371.39
Beilstein:
4119211
EC Number:
200-708-1
MDL number:
MFCD00064313
UNSPSC Code:
41116107
PubChem Substance ID:
329822591
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 785
traceable to Ph. Eur. A1000000
traceable to USP 1033203

API family

ampicillin

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

215 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

[Na+].CC1(C)SC2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C([O-])=O

InChI

1S/C16H19N3O4S.Na/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);/q;+1/p-1/t9-,10-,11+,14-;/m1./s1

InChI key

KLOHDWPABZXLGI-YWUHCJSESA-M

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Ampicillin Sodium may be used as a pharmaceutical secondary reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography with ultra violet detection and second-derivative spectrophotometry, respectively.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Mode of Action: This is a ß-lactam antibiotic that inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane.

Mode of Resistance: Administration with ß-lactamase cleaves the ß-lactam ring of Ampicillin and inactivates it.

Antimicrobial Spectrum: Includes both gram-positive (similar to benzylpenicillin) and gram-negative bacteria (similar to tetracyclines and chloramphenicol.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA2732 in the slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.
Description
Pricing

1033000

Ampicillin, United States Pharmacopeia (USP) Reference Standard

A1100000

Ampicillin trihydrate, European Pharmacopoeia (EP) Reference Standard

A1000000

Ampicillin, anhydrous, European Pharmacopoeia (EP) Reference Standard

PHR1393

Ampicillin Trihydrate, Pharmaceutical Secondary Standard; Certified Reference Material

1033203

Ampicillin sodium, United States Pharmacopeia (USP) Reference Standard

1033407

Ampicillin trihydrate, United States Pharmacopeia (USP) Reference Standard

1033247

Ampicillin System Suitability Mixture, United States Pharmacopeia (USP) Reference Standard

BP785

Anhydrous ampicillin, British Pharmacopoeia (BP) Reference Standard

BP021

Ampicillin trihydrate, British Pharmacopoeia (BP) Reference Standard

PHR9060

D-(−)-α-Phenylglycine, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR9105

(2R)-2-[(2,2-Dimethylpropanoyl)amino]-2-phenylacetic acid, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR2838

Ampicillin, pharmaceutical secondary standard, certified reference material

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H317 - H334

Precautionary Statements

P261 - P280 - P342 + P311

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAC4219
LRAD0378
LRAA9206
LRAC4219
LRAA2732

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Ampicillin meets USP testing specifications

Sigma-Aldrich

A1593

Ampicillin

Ampicillin trihydrate 900-1050 μg/mg anhydrous basis (HPLC)

Sigma-Aldrich

A6140

Ampicillin trihydrate

Ampicillin anhydrous, 96.0-102.0% (anhydrous basis)

Sigma-Aldrich

A9393

Ampicillin

Supelco

Supelco

PHR1847

Ceftazidime

Anhydrous ampicillin British Pharmacopoeia (BP) Reference Standard

BP785

Anhydrous ampicillin

Determination of mixtures of ampicillin and cloxacillin in pharmaceuticals by second-derivative spectrophotometry
Morelli B
Analytica Chimica Acta, 209, 175-184 (1988)
Felipe H Coutinho et al.
Microbial ecology, 68(3), 441-452 (2014-05-14)
Bacterial resistance to antibiotics has become a public health issue. Over the years, pathogenic organisms with resistance traits have been studied due to the threat they pose to human well-being. However, several studies raised awareness to the often disregarded importance
Hazem E Ghoneim et al.
The Journal of infectious diseases, 209(9), 1459-1468 (2013-11-26)
Secondary bacterial pneumonia is a significant cause of morbidity and mortality during influenza, despite routine use of standard antibiotics. Antibiotic-induced immunopathology associated with bacterial cell wall lysis has been suggested to contribute to these poor outcomes. Using Streptococcus pneumoniae in
Yuraporn Sahasakul et al.
The British journal of nutrition, 112(3), 408-415 (2014-06-17)
Lactobacilli are indigenous microbes of the stomach of rodents, with much lower numbers being present in mice fed a purified diet than in those fed a non-purified diet. We postulated that gastric emptying (GE) is responsible for the different colonisation
Bacterial endocarditis following lithotripsy: an unusual complication caused by a non-invasive procedure.
Alessandra Soriano et al.
The Israel Medical Association journal : IMAJ, 16(12), 803-804 (2015-01-30)
View All Related Papers

Protocols

USP HPLC Analysis of Ampicillin Sodium on Ascentis® Express C18

USP HPLC Analysis of Ampicillin Sodium on Ascentis® Express C18

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