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PHR1090

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Dopamine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

2-(3,4-Dihydroxyphenyl)ethylamine hydrochloride, 3,4-Dihydroxyphenethylamine hydrochloride, 3-Hydroxytyramine hydrochloride, 4-(2-Aminoethyl)-1,2-benzenediol hydrochloride

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About This Item

Linear Formula:
(HO)2C6H3CH2CH2NH2·HCl
CAS Number:
62-31-7
Molecular Weight:
189.64
Beilstein:
3656720
EC Number:
200-527-8
MDL number:
MFCD00012898
UNSPSC Code:
41116107
PubChem Substance ID:
329823112
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 468
traceable to Ph. Eur. D2690000
traceable to USP 1225204

API family

dopamine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

248-250 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl[H].NCCc1ccc(O)c(O)c1

InChI

1S/C8H11NO2.ClH/c9-4-3-6-1-2-7(10)8(11)5-6;/h1-2,5,10-11H,3-4,9H2;1H

InChI key

CTENFNNZBMHDDG-UHFFFAOYSA-N

Gene Information

human ... ADRB1(153)

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Dopamine is a neurotransmitter which is a naturally occurring catecholamine. Dopamine hydrochloride salt is indicated as a medicine for the treatment of acute congestive and renal failures.

Application

Dopamine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry, colorimetry and chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA7131 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317

Hazard Classifications

Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD3319
LRAD1017
LRAC1333
P500090
LRAA7131

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Rapid Spectrophotometric Determination Of Dopamine Hydrochloride With Chloramine - T
Nagaraja P, et al.
Indian Journal of Pharmaceutical Sciences, 60(2), 99-99 (2016)
Spectrophotometric methods for the determination of certain catecholamine derivatives in pharmaceutical preparations
Nagaraja P, et al.
Talanta, 46(1), 39-44 (1998)
Intropin (dopamine hydrochloride) intravenous admixture compatibility
Gardella LA, et al.
American Journal of Hospital Pharmacy, 32(6), 575-578 (1975)
Frank J Meye et al.
Trends in pharmacological sciences, 35(1), 31-40 (2013-12-18)
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Hanneke E M den Ouden et al.
Neuron, 80(4), 1090-1100 (2013-11-26)
Serotonin and dopamine are speculated to subserve motivationally opponent functions, but this hypothesis has not been directly tested. We studied the role of these neurotransmitters in probabilistic reversal learning in nearly 700 individuals as a function of two polymorphisms in
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