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PHR1076

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Metoprolol Tartrate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

(±)-Metoprolol (+)-tartrate salt, (±)1-(Isopropylamino)-3-[p-(β-methoxyethyl)phenoxy]-2-propanol (+)-tartrate salt, Lopressor

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About This Item

Linear Formula:
(C15H25NO3)2 · C4H6O6
CAS Number:
56392-17-7
Molecular Weight:
684.81
EC Number:
260-148-9
MDL number:
MFCD00056257
UNSPSC Code:
41116107
PubChem Substance ID:
329823099
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 540
traceable to Ph. Eur. M1830000
traceable to USP 1441301

API family

metoprolol

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

O[C@H]([C@@H](O)C(O)=O)C(O)=O.COCCc1ccc(OCC(O)CNC(C)C)cc1.COCCc2ccc(OCC(O)CNC(C)C)cc2

InChI

1S/2C15H25NO3.C4H6O6/c2*1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3;5-1(3(7)8)2(6)4(9)10/h2*4-7,12,14,16-17H,8-11H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)/t;;1-,2-/m..1/s1

InChI key

YGULWPYYGQCFMP-CEAXSRTFSA-N

Gene Information

human ... ADRB1(153)

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General description

Metoprolol Tartrate is a β-blocking drug, showing antihypertensive and anti-ischemic effects. It is widely used in the treatment of hypertension and helps in controlling ventricular response in patients with atrial fibrillation.

Application

Metoprolol Tartrate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations using densitometric technique and spectrophotometric technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA6905 in the slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.
Description
Pricing

1441301

Metoprolol tartrate, United States Pharmacopeia (USP) Reference Standard

Y0000145

Metoprolol impurity A, European Pharmacopoeia (EP) Reference Standard

1441243

Metoprolol Related Compound B, United States Pharmacopeia (USP) Reference Standard

1441254

Metoprolol Related Compound C, United States Pharmacopeia (USP) Reference Standard

1441265

Metoprolol Related Compound D, United States Pharmacopeia (USP) Reference Standard

1441298

Metoprolol succinate, United States Pharmacopeia (USP) Reference Standard

1441232

Metoprolol Related Compound A, United States Pharmacopeia (USP) Reference Standard

1441287

Metoprolol fumarate, United States Pharmacopeia (USP) Reference Standard

BP540

Metoprolol tartrate, British Pharmacopoeia (BP) Reference Standard

PHR9038

Metoprolol EP Impurity B, reference material

PHR9039

Metoprolol EP Impurity G, reference material

PHR9068

Metoprolol EP Impurity H, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR2509

Metoprolol Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

PHR9101

Metoprolol EP Impurity E, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR2510

Metoprolol Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2511

Metoprolol succinate, Pharmaceutical Secondary Standard; Certified Reference Material

PHR3046

Metoprolol Fumarate, pharmaceutical secondary standard, certified reference material

Pictograms

Health hazardEnvironment
GHS08,GHS09

Signal Word

Warning

Hazard Statements

H361d,H411

Hazard Classifications

Aquatic Chronic 2 - Repr. 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAC1767
LRAA6905
P500076

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A validated HPLC method for estimation of metoprolol in human plasma
Aqil M, et al.
Acta Chromatographica, 19, 130-130 (2007)
Densitometric determination of metoprolol tartrate in pharmaceutical dosage forms
Vujic Z, et al.
Journal of Pharmaceutical and Biomedical Analysis, 15(5), 581-585 (1997)
Current Cardiovascular Drugs, 15(4), 581-585 (2005)
AAS and spectrophotometric determination of propranolol HCl and metoprolol tartrate
El-Ries MA, et al.
Journal of Pharmaceutical and Biomedical Analysis, 24(2), 179-187 (2000)
Mehmet Ozaydin et al.
European heart journal, 34(8), 597-604 (2012-12-13)
Carvedilol and N-acetyl cysteine (NAC) have antioxidant and anti-inflammatory properties. Aim was to evaluate the efficacy of metoprolol, carvedilol, and carvedilol plus NAC on the prevention of post-operative atrial fibrillation (POAF). Patients undergoing cardiac surgery (n = 311) were randomized
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