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PHR1011

Supelco

Ethylparaben

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Ethyl 4-hydroxybenzoate, EP, Ethylparaben

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About This Item

Linear Formula:
HOC6H4CO2C2H5
CAS Number:
120-47-8
Molecular Weight:
166.17
Beilstein:
1101972
EC Number:
204-399-4
MDL number:
MFCD00002353
UNSPSC Code:
41116107
eCl@ss:
39024522
PubChem Substance ID:
329823042
E Number:
E214
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. E2425000
traceable to USP 1267000

API family

parabens

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

297-298 °C (lit.)

mp

114-117 °C (lit.)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CCOC(=O)c1ccc(O)cc1

InChI

1S/C9H10O3/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6,10H,2H2,1H3

InChI key

NUVBSKCKDOMJSU-UHFFFAOYSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Ethylparaben may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography (HPLC).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3158 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

Product No.
Description
Pricing

PHR1010

Propylparaben, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1012

Methylparaben, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1022

Butylparaben, Pharmaceutical Secondary Standard; Certified Reference Material

1084000

Butylparaben, United States Pharmacopeia (USP) Reference Standard

1267000

Ethylparaben, United States Pharmacopeia (USP) Reference Standard

1432005

Methylparaben, United States Pharmacopeia (USP) Reference Standard

1577008

Propylparaben, United States Pharmacopeia (USP) Reference Standard

E2425000

Ethyl parahydroxybenzoate, European Pharmacopoeia (EP) Reference Standard

P3650000

Propyl parahydroxybenzoate, European Pharmacopoeia (EP) Reference Standard

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD4286
LRAC4269
LRAC3158
LRAB3628
LRAB3689

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Determination of combined p-hydroxy benzoic acid preservatives in a liquid pharmaceutical formulation by HPLC
Shabir GA.
Journal of Pharmaceutical and Biomedical Analysis, 34(1), 207-213 (2004)
Maw-Rong Lee et al.
Journal of chromatography. A, 1120(1-2), 244-251 (2006-03-04)
This study evaluated supercritical fluid extraction (SFE) combined with liquid chromatography-mass spectrometry (LC-MS) to determine trace preservatives and antioxidants including methylparaben (MP), ethylparaben (EP), propylparaben (PP), butylparaben (BP), butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), alpha-tocopherol (alpha-t) and alpha-tocopherol acetate (alpha-ta)
Suzanne Abbas et al.
Drug metabolism and pharmacokinetics, 25(6), 568-577 (2010-10-12)
Parabens (alkyl esters of 4-hydroxybenzoic acid) are widely used as preservatives in drugs, cosmetic products, and foodstuffs. Safety concerns have recently increased due to the potential health risks associated to exposure to large amounts of these substances. Biotransformation of parabens
Sawsan El Hussein et al.
Experimental dermatology, 16(10), 830-836 (2007-09-12)
Concern is continuously raised about the safety of parabens which are present in most of the cosmetic preparations. In this investigation, methyl-, ethyl-, propyl- and butyl paraben (MP, EP, PP, BP), in a commercial cosmetic lotion, were deposited on human
S Nicoli et al.
Journal of pharmaceutical sciences, 97(11), 4830-4839 (2008-03-05)
This work aims at investigating the nicotinamide (NA)-ethyl-paraben (EP) binary system both in solution and in the solid state. In particular, the apparent EP solubility in water was studied in the presence of different NA concentrations (between 0.28 and 1.64
View All Related Papers

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