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F8798

Sigma-Aldrich

Folic acid

meets USP testing specifications

Synonym(s):

PteGlu, Pteroyl-L-glutamic acid, Vitamin M

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About This Item

Empirical Formula (Hill Notation):
C19H19N7O6
CAS Number:
59-30-3
Molecular Weight:
441.40
Beilstein:
100781
EC Number:
200-419-0
MDL number:
MFCD00079305
UNSPSC Code:
12352100
eCl@ss:
34058014
PubChem Substance ID:
24894977
NACRES:
NA.21

biological source

synthetic (organic)

Quality Level

200

Agency

USP/NF
meets USP testing specifications

Assay

97.0-102.0% dry basis

form

solid

color

yellow

mp

>285 °C

application(s)

cell analysis
pharmaceutical (small molecule)

SMILES string

NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O

InChI

1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

InChI key

OVBPIULPVIDEAO-LBPRGKRZSA-N

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General description

Folic acid, also known as pteroyl-L-glutamic acid, belongs to the vitamin B group. The conformational analysis of folic acid in the solution has been reported based on nuclear magnetic resonance (NMR) and theoretical calculations. The reaction kinetics of the photodecomposition under ultraviolet radiation has been investigated. This product is a high quality pharmacopoeia product that meets the testing specifications of USP (United States Pharmacopoeia). It can be employed in research and pilot studies.

Application

Folic acid has been used in a study to investigate its protective effects against the toxicity caused by valproic acid (VPA) on maternal liver tissue. It has also been used as standard for the quantification of plasma folic acid by reversed-phase HPLC.

WGK

WGK 1

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Ultrastructural investigation of the protective role of folic acid and vitamin E against toxic effects of valproic acid on maternal liver tissue during period of gestation.
Ozlem P Baran et al.
Saudi medical journal, 27(3), 407-409 (2006-03-15)
Ultraviolet photodegradation of folic acid.
Off MK, et al.
Journal of Photochemistry and Photobiology. B, Biology, 80(1), 47-55 (2005)
Solution structure of folic acid: Molecular mechanics and NMR investigation.
Bonechi C, et al.
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 60(7), 1411-1419 (2004)
Carolyn Tam et al.
Obstetrics and gynecology international, 2012, 485179-485179 (2012-04-25)
There are increasing concerns that exposure to unmetabolized folic acid, which results from folic acid intakes that overwhelm the liver's metabolic capacity, may be associated with adverse effects. In this paper, we examined the folic acid status of women of
Tor A Strand et al.
Pediatrics, 135(4), e918-e926 (2015-03-25)
Folate and vitamin B-12 are important for growth. Many children in low- and middle-income countries have inadequate intakes of these nutrients. We undertook a randomized, placebo controlled double-blind trial in 1000 North Indian children, 6 to 35 months of age
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Articles

Folic Acid and Tetrahydrofolates in Cell Culture

Importance and uses of folic acid in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures. Folic acid and its reduced derivative(s), such as folinic acid, are an essential water soluble vitamins added to virtually all cell culture media.

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