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BP423

Phytomenadione

British Pharmacopoeia (BP) Reference Standard

Synonym(s):

Vitamin K1, 2-Methyl-3-phytyl-1,4-naphthoquinone, 3-Phytylmenadione, Phylloquinone, Vitamin K1(20)

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About This Item

Empirical Formula (Hill Notation):
C31H46O2
CAS Number:
84-80-0
Molecular Weight:
450.70
Beilstein:
2568816
EC Number:
201-564-2
MDL number:
MFCD00214063
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

phytomenadione

form

viscous liquid (Clear)

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

BP

refractive index

n20/D 1.527 (lit.)

mp

−20 °C (lit.)

density

0.984 g/mL at 25 °C (lit.)

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

storage temp.

2-8°C

SMILES string

O=C(C1=CC=CC=C21)C(C)=C(C/C=C(CCC[C@@H](CCC[C@H](C)CCCC(C)C)C)\C)C2=O

InChI

1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1

InChI key

MBWXNTAXLNYFJB-NKFFZRIASA-N

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General description

Phytomenadione is a synthetic lipid-soluble forms of vitamin K1, and works as an essential cofactor for the post-translational γ-carboxyglutamate (Gla) residues in several blood coagulation factors. It is used to treat coagulopathies caused by anticoagulant toxicosis.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Phytomenadione BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Phytomenadione Injection
  • Phytomenadione Tablets

    • Packaging

    Unit quantity: 0.25 mL. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

    Other Notes

    Sales restrictions may apply.

    related product

    Product No.
    Description
    Pricing

    WGK

    WGK 1

    Flash Point(F)

    Not applicable

    Flash Point(C)

    Not applicable

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    Rapid HPLC assay for the assessment of vitamin K1, A, E and beta-carotene status in children (7-19 years)
    Jakob E and Elmadfa I
    Internat. J. Vit. Nutr. Res., 65(1), 31-35 (1995)
    HPLC-APCI-MS for the determination of vitamin K1 in human plasma: method and clinical application
    Song Q, et al.
    Journal of Chromatography. B, Biomedical Sciences and Applications, 875(2), 541-545 (2008)
    Papich GM, et al. et al.
    Saunders Handbook of Veterinary Drugs, (4), 637-638 (2016)

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