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B1390

Supelco

Bisacodyl

analytical standard, for drug analysis

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About This Item

Empirical Formula (Hill Notation):
C22H19NO4
CAS Number:
603-50-9
Molecular Weight:
361.39
EC Number:
210-044-4
MDL number:
MFCD00038039
UNSPSC Code:
41116107
PubChem Substance ID:
329773183

grade

analytical standard, for drug analysis

Quality Level

100

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

2-8°C

SMILES string

CC(=O)Oc1ccc(cc1)C(c2ccc(OC(C)=O)cc2)c3ccccn3

InChI

1S/C22H19NO4/c1-15(24)26-19-10-6-17(7-11-19)22(21-5-3-4-14-23-21)18-8-12-20(13-9-18)27-16(2)25/h3-14,22H,1-2H3

InChI key

KHOITXIGCFIULA-UHFFFAOYSA-N

Gene Information

human ... CHRM4(1132)

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General description

Bisacodyl is a diphenylmethane derivative, mainly used as a stimulant laxative for treating constipation.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315 - H319 - H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

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Sigma-Aldrich

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Sigma-Aldrich

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Stephen Vanner et al.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 25(12), 663-666 (2011-12-17)
Despite the wealth of research investigating bowel cleansing efficacy, there are very little data on the timing or frequency of bowel movements after each agent is ingested. To examine the effect of each component of a three-day combined sodium picosulphate⁄magnesium
Nobutomo Ikarashi et al.
American journal of physiology. Gastrointestinal and liver physiology, 301(5), G887-G895 (2011-08-27)
The purpose of this study was to investigate the role of aquaporin3 (AQP3) in the colon in the laxative effect of bisacodyl. After oral administration of bisacodyl to rats, AQP3, macrophages, cyclooxygenase 2 (COX2), and prostaglandin E(2) (PGE(2)) were examined
Nobutomo Ikarashi et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 45(1-2), 73-78 (2011-11-17)
Patients with severe constipation are treated with combinations of several different laxatives. The purpose of this study is to examine whether the concomitant use of different laxatives enhances the laxative effect, using an osmotic laxative, magnesium sulphate (MgSO₄), and a
Dina Kao et al.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 25(12), 657-662 (2011-12-17)
The ideal bowel cleansing regimen for colonoscopy has yet to be determined. To compare the cleansing efficacy, and patient tolerability and safety of four bowel preparation regimens. A total of 834 patients undergoing outpatient colonoscopy were randomly assigned to one
L Rodriguez et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 24(11), 1023-e545-1023-e545 (2012-07-05)
Describe the association of internal anal sphincter (IAS) relaxation with colonic high- amplitude peristaltic contractions (HAPCs). Retrospective review of colon manometry tracings of children with constipation to determine the IAS relaxation characteristics associated with HAPC's (HAPC-IASR) events and compare them
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