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A5131

Sigma-Aldrich

L-Arginine monohydrochloride

reagent grade, ≥98% (HPLC), powder

Synonym(s):

(S)-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride, (S)-(+)-Arginine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C6H14N4O2 · HCl
CAS Number:
Molecular Weight:
210.66
Beilstein:
3631658
EC Number:
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26

grade

reagent grade

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white

mp

>235 °C

solubility

H2O: 50 mg/mL

application(s)

cell analysis

SMILES string

Cl[H].N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1

InChI key

KWTQSFXGGICVPE-WCCKRBBISA-N

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Application

L-Arginine monohydrochloride has been used to study the effects of amino acids in promoting food consumption in Drosophila melanogaster. It has also been used to develop a non-invasive chronic pancreatitis model of rat.

Biochem/physiol Actions

L-Arginine is a semi-essential amino acid. This dibasic amino acid acts as a precursor for creatinine and is a natural constituent of most of the dietary proteins.
Substrate of nitric oxide synthase, which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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L-Arginine monohydrochloride certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

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Sigma-Aldrich

11009

L-Arginine

Arginine hydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1042601

Arginine hydrochloride

L-Arginine monohydrochloride EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP

SAFC

1.01544

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L-Arginine 99%, FCC, FG

Sigma-Aldrich

W381918

L-Arginine

Severe Chronic Pancreatitis due to Recurrent Acute Injury: Non-Invasive Chronic Pancreatitis Model of Rat
Surendra Sharma
Pancreas (2016)
Yang Liu et al.
Biochemical and biophysical research communications, 525(3), 620-625 (2020-03-03)
The circadian clock, a biochemical oscillator, plays a fundamental role in health and diseases. Ferroptosis, a type of regulated cell death driven by oxidative stress, is a prominent feature in iron-induced tissue injury. However, whether an impaired circadian clock contributes
J. P. Felix D'Mello
Amino Acids in Human Nutrition and Health (2012)
An internal sensor detects dietary amino acids and promotes food consumption in Drosophila
Zhe Yang
Nature (2017)
Yangyang Hu et al.
Journal of cellular physiology, 234(12), 21988-21998 (2019-05-07)
The severity of acute pancreatitis (AP) is greatly attributed to the pancreatic acinar cell (PAC) death response. It has been established that the apoptosis-inducing therapy can protect against experimental pancreatitis and have great clinical therapeutic potential. However, current pharmacologic agents

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