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84210

Sigma-Aldrich

Salicylic acid

puriss. p.a., ≥99.0% (T)

Synonym(s):

2-Hydroxybenzoic acid

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About This Item

Linear Formula:
2-(HO)C6H4CO2H
CAS Number:
Molecular Weight:
138.12
Beilstein:
774890
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.21

vapor density

4.8 (vs air)

Quality Level

vapor pressure

1 mmHg ( 114 °C)

grade

puriss. p.a.

Assay

≥99.0% (T)

form

powder

ign. residue

≤0.05% (as SO4)

loss

≤0.5% loss on drying

bp

211 °C (lit.)

mp

158-161 °C (lit.)
158-161 °C

solubility

96% ethanol: 0.1 g/mL, clear

anion traces

chloride (Cl-): ≤100 mg/kg
sulfate (SO42-): ≤200 mg/kg

cation traces

Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤500 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

SMILES string

OC(=O)c1ccccc1O

InChI

1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)

InChI key

YGSDEFSMJLZEOE-UHFFFAOYSA-N

Gene Information

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General description

Salicylic acid is an aromatic phenolic derivative. It plays an important role in various physiological processes in plants, such as thermogenesis, ethylene synthesis and fruit ripening.

Application

Salicylic acid may be used for the quantitative estimation of nitrate in plant materials by colorimetric method. It may be used in the synthesis of 2,5-dihydroxybenzoic acid (gentistic acid).

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 2

WGK

WGK 1

Flash Point(F)

closed cup

Flash Point(C)

closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Salicylic acid United States Pharmacopeia (USP) Reference Standard

USP

1609002

Salicylic acid

Salicylic acid European Pharmacopoeia (EP) Reference Standard

S0200000

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Salicylic acid phyproof® Reference Substance

PHL80529

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Salicylic acid certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Supelco

52341

Salicylic acid

Salicylic acid British Pharmacopoeia (BP) Reference Standard

BP775

Salicylic acid

Eagleson M.
Concise Encyclopedia Chemistry, 449-449 (1994)
Salicylic acid activates nitric oxide synthesis in Arabidopsis.
Zottini M, et al.
Journal of Experimental Botany, 58(6), 1397-1405 (2007)
Rapid colorimetric determination of nitrate in plant tissue by nitration of salicylic acid1.
Cataldo DA, et al.
Communications in Soil Science and Plant Analysis, 6(1), 71-80 (1975)
Michal Harel et al.
Cell, 179(1), 236-250 (2019-09-10)
Immunotherapy has revolutionized cancer treatment, yet most patients do not respond. Here, we investigated mechanisms of response by profiling the proteome of clinical samples from advanced stage melanoma patients undergoing either tumor infiltrating lymphocyte (TIL)-based or anti- programmed death 1
E Benfeldt et al.
Acta dermato-venereologica, 79(5), 338-342 (1999-09-24)
Our aim was to simultaneously investigate 2 techniques for in vivo sampling of peripheral compartment pharmacokinetics after systemic administration of acetylsalicylic acid. Ten volunteers were given 2 g acetylsalicylic acid orally. Blood samples and dialysates from 4 microdialysis probes inserted

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