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00180585

Hyperoside

primary reference standard

Synonym(s):

Quercetin 3-D-galactoside, 3,3′,4′,5,7-Pentahydroxyflavone 3-D-galactoside, Hyperin, Hyperoside

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About This Item

Empirical Formula (Hill Notation):
C21H20O12
CAS Number:
482-36-0
Molecular Weight:
464.38
Beilstein:
5784795
EC Number:
207-580-6
MDL number:
MFCD00016933
UNSPSC Code:
85151701
PubChem Substance ID:
329747012
NACRES:
NA.24

grade

primary reference standard

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

HWI

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

SMILES string

OC[C@H]1O[C@@H](OC2=C(Oc3cc(O)cc(O)c3C2=O)c4ccc(O)c(O)c4)[C@H](O)[C@@H](O)[C@H]1O

InChI

1S/C21H20O12/c22-6-13-15(27)17(29)18(30)21(32-13)33-20-16(28)14-11(26)4-8(23)5-12(14)31-19(20)7-1-2-9(24)10(25)3-7/h1-5,13,15,17-18,21-27,29-30H,6H2/t13-,15+,17+,18-,21+/m1/s1

InChI key

OVSQVDMCBVZWGM-DTGCRPNFSA-N

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General description

Hyperoside is a flavonol glycoside compound used in Traditional Chinese medicine for its various beneficial effects, such as anti-inflammatory, anti-oxidant, anti-viral, and anti-cancer.
Produced and qualified by HWI pharma services GmbH.
Exact content measured by quantitative NMR can be found on the certificate.

Application

The primary reference standard can be used for identification, assay, and purity testing, method development, and validation.

It can also be used as follows:

  • Development of an ultra performance liquid chromatography-mass spectrometric method to determine hyperoside in rat plasma samples following sample treatment by protein precipitation and liquid-liquid extraction
  • Multi-residue analysis of hyperoside, isoquercitrin, and eleutheroside E in botanical samples of Apocynum venetum L. and Eleutherococcus senticosus used in traditional Chinese medicine by HPLC combined with diode array detection (DAD)
  • Ionic liquid vacuum microwave-assisted extraction (ILVMAE) of rutin, hyperoside, and hesperidin from Sorbus tianschanica leaf samples for their subsequent quantification by HPLC
  • Simultaneous detection and quantification of vitexin, rutin, hyperoside, and quercetin in hawthorn flower and leaf extract samples using high-performance liquid chromatography combined with spectrophotometric detection (HPLC-UV)

Biochem/physiol Actions

Protects against peroxide-induced oxidative damage to cells by scavenging reactive oxygen species and enhancing activity of anti-oxidant enzymes, in particular, catalase and glutathione peroxidase.

Other Notes

A flavonol glycoside widely distribute in plants, including mimosa and St. John′s wort.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
HWI03170-1
HWI03170
HWI01245
HWI02328-1
HWI02328

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Rutin trihydrate analytical standard

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Quercetin 3-glucoside analytical standard

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Isovitexin ≥98.0% (HPLC)

Sigma-Aldrich

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Isovitexin

Sae-Kwang Ku et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 53, 197-204 (2012-12-12)
The potential anticoagulant activities of two single compounds, isorhamnetin-3-O-galactoside (IMG) and hyperoside, from Oenanthe javanica, were tested. The anticoagulant activities were investigated by measuring activated partial thromboplastin time (aPTT) and prothrombin time (PT), and the ability to inhibit production of
Xi-Hua Cui et al.
Bioresource technology, 102(21), 10072-10079 (2011-09-16)
The effects of inoculum density, aeration volume and culture period on accumulation of biomass and secondary metabolites in adventitious roots of Hypericum perforatum in balloon type airlift bioreactors (3 l capacity) were investigated. The greatest increment of biomass as well
Lei Zhou et al.
Journal of medicinal food, 15(5), 461-468 (2012-03-24)
Diabetic nephropathy (DN) is an important diabetic complication, and podocyte apoptosis plays a critical role in the development of DN. In the present study, we examined the preventive effect of the total flavone glycosides of Flos Abelmoschus manihot (TFA) on
Jianming Guo et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 18(14), 1250-1254 (2011-07-26)
Depression is the most common psychiatric comorbidity in patients with epilepsy. Searching for antiepileptic (anticonvulsant) and antidepressant-like medicines from natural products is very important for the treatment of this disease. The flower of Abelmoschus manihot (Linn.) Medicus has been reported
Anti-inflammatory activity of hyperoside through the suppression of nuclear factor-?B activation in mouse peritoneal macrophages.
Kim SJ, Um JY, Lee JY
American Journal of Chinese Medicine, 39(1), 171-181 (2011)
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