SCT246
BioTracker BioCyTASQ G-Quadruplex (G4) Cell Probe
Synonym(s):
G quadruplex probe, G4 ligand, G4 probe, G4 tetrad probe, Live Cell Imaging Probe
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About This Item
UNSPSC Code:
41106514
NACRES:
NA.47
Recommended Products
packaging
vial of 1 mg
Quality Level
manufacturer/tradename
Millipore
growth mode
N/A
technique(s)
DNA sequencing: suitable
RNA extraction: suitable
nucleic acid detection: suitable
detection method
fluorometric
shipped in
dry ice
storage temp.
−20°C
Application
G-quadruplexes are four-stranded structures comprising stacked G tetrads (G4) formed within certain guanine-rich nucleic acid sequences. G-quadruplexes are enriched in open chromatin regions but are also present in the nucleolus and cytoplasm. The formation of G4 structures is dynamic and cell-type specific, suggestive of interaction with transcription factors and other proteins. For this reason G-quadruplexes have garnered intense interest for their potential role in transcriptional regulation.
The BioTracker™ BioCyTASQ G-quadruplex G4 cell probe is optimized for detection of G-quadruplexes. BioCyTASQ utilizes the template-assembled synthetic G-quartets (TASQ) concept as a biomimetic ligand for G-quadruplexes, a design which results in high specificity for folded G4.
References
1. Nat. Chem. 2021, 13(7): 626-633
2. ACS Chem Biol. 2021, 16(5): 905-914
The BioTracker™ BioCyTASQ G-quadruplex G4 cell probe is optimized for detection of G-quadruplexes. BioCyTASQ utilizes the template-assembled synthetic G-quartets (TASQ) concept as a biomimetic ligand for G-quadruplexes, a design which results in high specificity for folded G4.
References
1. Nat. Chem. 2021, 13(7): 626-633
2. ACS Chem Biol. 2021, 16(5): 905-914
Purity: > 98% confirmed by HPLC, HNMR, LC-MS and elemental analysis.
Features and Benefits
BioCyTASQ detects ribosomal RNA associated with perinuclear rough ER regions. BioCyTASQ is suitable for G4 capture pull-down assays as well as cellular imaging.2 BioCyTASQ G4 probe is not recommended for live-cell imaging applications. The biotinylated BioTracker BioCyTASQ G-quadruplex G4 cell probe makes is a powerful tool for biochemical and cellular analysis of G4 by fluorescent detection when used with a fluorescent streptavidin.
Physical form
Lyophilized. White solid.
Storage and Stability
Store BioTracker BioCyTASQ G-quadruplex G4 cell probe at -20°C, desiccated and protected from light
Other Notes
Fluorescent detection of nucleic acid G4 quadruplexes in cells and tissues
Legal Information
BioTracker is a trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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