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CBL1348

Sigma-Aldrich

Anti-Integrin beta1 Antibody, clone HM beta 1.1

clone HM beta 1.1, from hamster

Synonym(s):

CD29 antigen, Fibronectin receptor subunit beta, Integrin VLA-4 subunit beta, fibronectin receptor beta subunit, integrin VLA-4 beta subunit, integrin beta 1, integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen

CD29 includes MDF2,

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

hamster

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

HM beta 1.1, monoclonal

species reactivity

human, mouse

technique(s)

immunocytochemistry: suitable

isotype

IgG

NCBI accession no.

NP_002202.2

UniProt accession no.

P09055

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... ITGB1(3688)
mouse ... Itgb1(16412)

General description

Integrin beta 1is also known as CD29. It is a transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits, forming the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions such as hemostasis, embryonic development, wound repair, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and on adjacent cells. The clustering of integrins on a cell surface leads to the formation of focal contacts. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression. Clone HM beta 1.1 is reported to inhibit beta 1 integrin mediated adhesion.

Specificity

Other species have not been tested.

Immunogen

Epitope: Full length
Purified mouse VLA-4 antigen

Application

Detect Integrin beta1 using this Anti-Integrin beta1 Antibody, clone HM beta 1.1 validated for use in IC.
Research Category
Cell Structure
Research Sub Category
Integrins

Quality

Routinely evaluated by immunocytochemistry on mouse NIH3T3, A431 cells.

Target description

130 kDa

Physical form

Format: Purified
Protein G Purified
Purified in PBS with 0.05% NaN3.

Storage and Stability

Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.

Analysis Note

Control
NIH3T3, A431

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Fahmy A Mamuya et al.
American journal of physiology. Renal physiology, 313(4), F1026-F1037 (2017-07-14)
The renal collecting duct (CD) contains two major cell types, intercalated (ICs) and principal cells (PCs). A previous report showed that deletion of β1-integrin in the entire renal CD causes defective CD morphogenesis resulting in kidney dysfunction. However, subsequent deletion

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