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869006-M

Sigma-Aldrich

Thyroid Stimulating Hormone, Human Pituitary, Iodination Grade

Synonym(s):

Thyroid Stimulating Hormone, Human Pituitary, Iodination Grade, Thyrotropin, hTSH

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About This Item

CAS Number:
9002-71-5
UNSPSC Code:
12352202

biological source

human pituitary glands

Quality Level

100

sterility

non-sterile

Assay

≥95% (weight)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

technique(s)

enzyme immunoassay: suitable

impurities

≤0.1% hPRL (weight)
≤0.2% hGH, hFSH (weight)
≤0.3% hLH (weight)

solubility

0.05 M PBS: 1 mg/mL

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... TSHB(7252)

Related Categories

General description

Research area: Cell Signaling

Thyroid Stimulating Hormone is a glycoprotein produced by anterior pituitary gland. Its structure contains an alpha chain and a beta chain.

Biochem/physiol Actions

Thyroid stimulating hormone It exerts mild, continuous stimulation on the thyroid, resulting in maintenance of activity. TSH modulates the release of T3 and T4 from thyroid follicular cells. Thyroid Stimulating Hormone (TSH) primary targets thyroid gland and maintains thyroid activity. It regulates the release of T3 and T4 hormones from thyroid follicular cells. TSH binds to the TSH receptor (TSHR) and trigger Gs and Gq pathways. Activation of the Gs pathway stimulates iodide uptake, hormone secretion, and gland growth. The Gq pathway is involved in iodide organification for hormone synthesis. TSH secretion is inhibited by Somatostatin. Overexpression of TSH leads to hyperthyroidism, whereas lower TSH expression leads to hypothyroidism.

Warning

Toxicity: Standard Handling (A)

Unit Definition

1mg/ml in 0.05M PBS

Preparation Note

Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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