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5.08148

Sigma-Aldrich

Nefazodone Hydrochloride

Synonym(s):

Nefazodone Hydrochloride, 5-HT 2A Serotonin Receptor Antagonist, Nefazodone, BMY-13754, MJ-13754-1, Serzone, 5-HT2A Serotonin Receptor Antagonist, Nefazodone, BMY-13754, MJ-13754-1, Serzone

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About This Item

Empirical Formula (Hill Notation):
C25H32ClN5O2 · xHCl
CAS Number:
82752-99-6
Molecular Weight:
470.01 (free base basis)
MDL number:
MFCD00935760
UNSPSC Code:
12352200

Assay

≥99% (HPLC)

Quality Level

100

form

solid

potency

26 nM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

ethanol: 10 mM
DMSO: 25 mM

storage temp.

2-8°C

InChI

1S/C25H32ClN5O2.ClH/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22;/h3-6,8-11,20H,2,7,12-19H2,1H3;1H

InChI key

DYCKFEBIOUQECE-UHFFFAOYSA-N

General description

A potent 5-HT2A receptor antagonist (Kd = 26 nM), with moderate affinity for the alpha1-adrenergic receptor (Kd = 48 nM) and 5-HT1A receptor (Kd = 80 nM). Originally developed as a clinical antidepressant but discontinued in 2004, nefazodone (Serzone) still remains a specific inhibitor of certain serotonergic pathways. Nefazodone also has been reported to induce mitochondrial dysfuntion.

Warning

Toxicity: Standard Handling (A)

Other Notes

Kim, J.-A. et al. 2012. Toxicol. Lett.214, 175.
Cusack, B. et al. 1994. Psychopharmacol.114, 559.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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