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444286-M

Sigma-Aldrich

MMP-2 Inhibitor II

The MMP-2 Inhibitor II, also referenced under CAS 869577-51-5, controls the biological activity of MMP-2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):

MMP-2 Inhibitor II, (4-(4-(Methanesulfonamido)phenoxy)phenylsulfonyl)methyloxirane

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About This Item

Empirical Formula (Hill Notation):
C16H17NO6S2
CAS Number:
869577-51-5
Molecular Weight:
383.44
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥97% (HPLC)

form

solid

potency

2.4 μM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated
protect from light

color

white

solubility

DMSO: 200 mg/mL

storage temp.

−20°C

InChI

1S/C16H17NO6S2/c1-24(18,19)17-12-2-4-13(5-3-12)23-14-6-8-16(9-7-14)25(20,21)11-15-10-22-15/h2-9,15,17H,10-11H2,1H3

InChI key

ADEXXMLIERNFQB-UHFFFAOYSA-N

General description

An oxirane analog of SB-3CT, pMS (Cat. No. 444285) that acts as a selective, active site-binding, irreversible inhibitor of MMP-2 (Ki = 2.4 µM). Although less potent, it exhibits enhanced selectivity towards MMP-2 (Ki = 45 and 379 µM for MMP-1 and MMP-7, respectively) than SB-3CT, pMS.

Biochem/physiol Actions

Secondary Target
MMP-2 (Ki = 45 and 379 µM for MMP-1 and MMP-7, respectively)

Warning

Toxicity: Standard Handling (A)

Other Notes

Ikejiri, M., et al. 2005. J. Biol. Chem.280, 33992.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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